APPL1

From Wikipedia, the free encyclopedia

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

PDB rendering based on 2ela.

Available structures: 2ela, 2elb

Identifiers

Symbol(s)

APPL1; APPL; DIP13alpha

External IDs

OMIM: 604299 MGI: 1920243 HomoloGene: 32143

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • cytoplasm • endosome membrane • membrane • NuRD complex
Biological Process:	• cell cycle • signal transduction • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012096 (mRNA)
NP_036228 (protein)

XM_975639 (mRNA)
XP_980733 (protein)

Location

Chr 3: 57.24 - 57.28 Mb

Chr 14: 25.75 - 25.8 Mb

Pubmed search

[1]

[2]

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1, also known as APPL1, is a human gene.^[1]

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.^[1]

[edit] References

^ ^a ^b Entrez Gene: APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Mitsuuchi Y, Johnson SW, Sonoda G, et al. (1999). "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.". Oncogene 18 (35): 4891–8. doi:10.1038/sj.onc.1203080. PMID 10490823.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. PMID 10718198.
Liu J, Yao F, Wu R, et al. (2002). "Mediation of the DCC apoptotic signal by DIP13 alpha.". J. Biol. Chem. 277 (29): 26281–5. doi:10.1074/jbc.M204679200. PMID 12011067.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yang L, Lin HK, Altuwaijri S, et al. (2003). "APPL suppresses androgen receptor transactivation via potentiating Akt activity.". J. Biol. Chem. 278 (19): 16820–7. doi:10.1074/jbc.M213163200. PMID 12621049.
Miaczynska M, Christoforidis S, Giner A, et al. (2004). "APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.". Cell 116 (3): 445–56. PMID 15016378.
Nechamen CA, Thomas RM, Cohen BD, et al. (2005). "Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling.". Biol. Reprod. 71 (2): 629–36. doi:10.1095/biolreprod.103.025833. PMID 15070827.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mao X, Kikani CK, Riojas RA, et al. (2006). "APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function.". Nat. Cell Biol. 8 (5): 516–23. doi:10.1038/ncb1404. PMID 16622416.
Nechamen CA, Thomas RM, Dias JA (2007). "APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.". Mol. Cell. Endocrinol. 260-262: 93–9. doi:10.1016/j.mce.2006.08.014. PMID 17030088.
Cheng KK, Lam KS, Wang Y, et al. (2007). "Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.". Diabetes 56 (5): 1387–94. doi:10.2337/db06-1580. PMID 17287464.
Li J, Mao X, Dong LQ, et al. (2007). "Crystal structures of the BAR-PH and PTB domains of human APPL1.". Structure 15 (5): 525–33. doi:10.1016/j.str.2007.03.011. PMID 17502098.
Zhu G, Chen J, Liu J, et al. (2007). "Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.". EMBO J. 26 (14): 3484–93. doi:10.1038/sj.emboj.7601771. PMID 17581628.
Saito T, Jones CC, Huang S, et al. (2007). "The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation.". J. Biol. Chem. 282 (44): 32280–7. doi:10.1074/jbc.M704150200. PMID 17848569.