APOL3

From Wikipedia, the free encyclopedia

Apolipoprotein L, 3

Identifiers

APOL3; APOLIII; CG12-1

External IDs

OMIM: 607253 MGI: 1923011 HomoloGene: 45476

Gene ontology
Molecular Function:	• signal transducer activity • lipid transporter activity • lipid binding
Cellular Component:	• extracellular region
Biological Process:	• lipid transport • inflammatory response • lipoprotein metabolic process • positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_014349 (mRNA)
NP_055164 (protein)

XM_001005546 (mRNA)
XP_001005546 (protein)

Location

Chr 22: 34.87 - 34.89 Mb

Chr 15: 77.22 - 77.22 Mb

Pubmed search

[1]

[2]

Apolipoprotein L, 3, also known as APOL3, is a human gene.^[1]

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. In addition, expression of this gene is upregulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Six transcript variants encoding three different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: APOL3 apolipoprotein L, 3.

[edit] Further reading

Horrevoets AJ, Fontijn RD, van Zonneveld AJ, et al. (1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes.". Blood 93 (10): 3418–31. PMID 10233894.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Duchateau PN, Pullinger CR, Cho MH, et al. (2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.". J. Lipid Res. 42 (4): 620–30. PMID 11290834.
Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.". Genomics 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (2002). "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.". Genomics 79 (4): 539–46. doi:10.1006/geno.2002.6729. PMID 11944986.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.