APOL2

From Wikipedia, the free encyclopedia

Apolipoprotein L, 2

Identifiers

APOL2; APOL-II

External IDs

OMIM: 607252 MGI: 2444921 HomoloGene: 12785

Gene ontology
Molecular Function:	• receptor binding • high-density lipoprotein binding • lipid binding
Cellular Component:	• extracellular region • intracellular
Biological Process:	• lipid metabolic process • lipid transport • acute-phase response • multicellular organismal development • cholesterol metabolic process • lipoprotein metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_030882 (mRNA)
NP_112092 (protein)

XM_001000700 (mRNA)
XP_001000700 (protein)

Location

Chr 22: 34.95 - 34.97 Mb

Chr 15: 77.58 - 77.58 Mb

Pubmed search

[1]

[2]

Apolipoprotein L, 2, also known as APOL2, is a human gene.^[1]

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: APOL2 apolipoprotein L, 2.

[edit] Further reading

McGhee KA, Morris DW, Schwaiger S, et al. (2005). "Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs.". Schizophr. Res. 76 (2-3): 231–8. doi:10.1016/j.schres.2005.01.006. PMID 15949655.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (2002). "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.". Genomics 79 (4): 539–46. doi:10.1006/geno.2002.6729. PMID 11944986.
Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.". Genomics 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
Duchateau PN, Pullinger CR, Cho MH, et al. (2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.". J. Lipid Res. 42 (4): 620–30. PMID 11290834.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.