APOL1

From Wikipedia, the free encyclopedia

Apolipoprotein L, 1

Identifiers

APOL1; APO-L; APOL; APOL-I

External IDs

Gene ontology
Molecular Function:	• lipid transporter activity • lipid binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• lipid metabolic process • lipid transport • steroid metabolic process • cholesterol metabolic process • lipoprotein metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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n/a

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Refseq

NM_003661 (mRNA)
NP_003652 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 22: 34.98 - 34.99 Mb

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Pubmed search

[1]

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Apolipoprotein L, 1, also known as APOL1, is a human gene.^[1]

Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. The protein encoded by this gene is a secreted high density lipoprotein which binds to apolipoprotein A-I. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: APOL1 apolipoprotein L, 1.

[edit] Further reading

Duchateau PN, Pullinger CR, Orellana RE, et al. (1997). "Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L.". J. Biol. Chem. 272 (41): 25576–82. PMID 9325276.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Duchateau PN, Movsesyan I, Yamashita S, et al. (2000). "Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects.". J. Lipid Res. 41 (8): 1231–6. PMID 10946010.
Duchateau PN, Pullinger CR, Cho MH, et al. (2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.". J. Lipid Res. 42 (4): 620–30. PMID 11290834.
Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.". Genomics 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (2002). "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.". Genomics 79 (4): 539–46. doi:10.1006/geno.2002.6729. PMID 11944986.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, et al. (2003). "Apolipoprotein L-I is the trypanosome lytic factor of human serum.". Nature 422 (6927): 83–7. doi:10.1038/nature01461. PMID 12621437.
Kang MK, Kameta A, Shin KH, et al. (2003). "Senescence-associated genes in normal human oral keratinocytes.". Exp. Cell Res. 287 (2): 272–81. PMID 12837283.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lugli EB, Pouliot M, Portela Mdel P, et al. (2005). "Characterization of primate trypanosome lytic factors.". Mol. Biochem. Parasitol. 138 (1): 9–20. doi:10.1016/j.molbiopara.2004.07.004. PMID 15500911.
Albert TS, Duchateau PN, Deeb SS, et al. (2005). "Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL.". J. Lipid Res. 46 (3): 469–74. doi:10.1194/jlr.M400304-JLR200. PMID 15604524.
Pérez-Morga D, Vanhollebeke B, Paturiaux-Hanocq F, et al. (2005). "Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes.". Science 309 (5733): 469–72. doi:10.1126/science.1114566. PMID 16020735.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
Vanhollebeke B, Nielsen MJ, Watanabe Y, et al. (2007). "Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 4118–23. doi:10.1073/pnas.0609902104. PMID 17360487.