APOBEC3D

From Wikipedia, the free encyclopedia

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative)

Identifiers

External IDs

Gene ontology
Molecular Function:	• zinc ion binding • hydrolase activity • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines • metal ion binding
Biological Process:	• metal ion transport

Orthologs

Human

Mouse

Entrez

140564

n/a

Refseq

NM_152426 (mRNA)
NP_689639 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative), also known as APOBEC3D, is a human gene.^[1]

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.^[1]

[edit] References

^ ^a ^b Entrez Gene: APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative).

[edit] Further reading

Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.". Trends Genet. 19 (4): 207–16. PMID 12683974.
Harris RS, Liddament MT (2004). "Retroviral restriction by APOBEC proteins.". Nat. Rev. Immunol. 4 (11): 868–77. doi:10.1038/nri1489. PMID 15516966.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Jarmuz A, Chester A, Bayliss J, et al. (2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.". Genomics 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mariani R, Chen D, Schröfelbauer B, et al. (2003). "Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.". Cell 114 (1): 21–31. PMID 12859895.
Sawyer SL, Emerman M, Malik HS (2006). "Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.". PLoS Biol. 2 (9): E275. doi:10.1371/journal.pbio.0020275. PMID 15269786.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Dang Y, Wang X, Esselman WJ, Zheng YH (2006). "Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family.". J. Virol. 80 (21): 10522–33. doi:10.1128/JVI.01123-06. PMID 16920826.