APOBEC3C

From Wikipedia, the free encyclopedia

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C

Identifiers

APOBEC3C; APOBEC1L; PBI; ARDC2; ARDC4; ARP5; MGC19485; bK150C2.3

External IDs

Gene ontology
Molecular Function:	• molecular_function • RNA binding • zinc ion binding • hydrolase activity • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines • metal ion binding
Cellular Component:	• cellular_component
Biological Process:	• biological_process

Orthologs

Human

Mouse

Entrez

27350

n/a

Refseq

NM_014508 (mRNA)
NP_055323 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C, also known as APOBEC3C, is a human gene.^[1]

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control.^[1]

[edit] References

^ ^a ^b Entrez Gene: APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C.

[edit] Further reading

Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.". Trends Genet. 19 (4): 207-16. PMID 12683974.
Cullen BR (2006). "Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors.". J. Virol. 80 (3): 1067-76. doi:10.1128/JVI.80.3.1067-1076.2006. PMID 16414984.
Haché G, Mansky LM, Harris RS (2006). "Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance.". AIDS reviews 8 (3): 148-57. PMID 17078485.
Madsen P, Anant S, Rasmussen HH, et al. (1999). "Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1.". J. Invest. Dermatol. 113 (2): 162-9. doi:10.1046/j.1523-1747.1999.00682.x. PMID 10469298.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Jarmuz A, Chester A, Bayliss J, et al. (2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.". Genomics 79 (3): 285-96. doi:10.1006/geno.2002.6718. PMID 11863358.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mariani R, Chen D, Schröfelbauer B, et al. (2003). "Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.". Cell 114 (1): 21-31. PMID 12859895.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Yu Q, Chen D, König R, et al. (2005). "APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.". J. Biol. Chem. 279 (51): 53379-86. doi:10.1074/jbc.M408802200. PMID 15466872.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Langlois MA, Beale RC, Conticello SG, Neuberger MS (2005). "Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities.". Nucleic Acids Res. 33 (6): 1913-23. doi:10.1093/nar/gki343. PMID 15809227.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203-8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
Doehle BP, Schäfer A, Wiegand HL, et al. (2005). "Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion.". J. Virol. 79 (13): 8201-7. doi:10.1128/JVI.79.13.8201-8207.2005. PMID 15956565.
Rose KM, Marin M, Kozak SL, Kabat D (2005). "Regulated production and anti-HIV type 1 activities of cytidine deaminases APOBEC3B, 3F, and 3G.". AIDS Res. Hum. Retroviruses 21 (7): 611-9. doi:10.1089/aid.2005.21.611. PMID 16060832.
Muckenfuss H, Hamdorf M, Held U, et al. (2006). "APOBEC3 proteins inhibit human LINE-1 retrotransposition.". J. Biol. Chem. 281 (31): 22161-72. doi:10.1074/jbc.M601716200. PMID 16735504.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.