APOBEC2

From Wikipedia, the free encyclopedia

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2

PDB rendering based on 2nyt.

Available structures: 2nyt

Identifiers

Symbol(s)

APOBEC2; ARP1; ARCD1

External IDs

OMIM: 604797 MGI: 1343178 HomoloGene: 4941

Gene ontology
Molecular Function:	• RNA binding • RNA editase activity • cytidine deaminase activity • zinc ion binding • hydrolase activity • metal ion binding
Biological Process:	• mRNA editing • mRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006789 (mRNA)
NP_006780 (protein)

NM_009694 (mRNA)
NP_033824 (protein)

Location

Chr 6: 41.13 - 41.14 Mb

Chr 17: 47.88 - 47.9 Mb

Pubmed search

[1]

[2]

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2, also known as APOBEC2, is a human gene.^[1]

[edit] References

^ Entrez Gene: APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2.

[edit] Further reading

Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.". Trends Genet. 19 (4): 207–16. PMID 12683974.
Lau PP, Zhu HJ, Baldini A, et al. (1994). "Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene.". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8522–6. PMID 8078915.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Oka K, Kobayashi K, Sullivan M, et al. (1997). "Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice.". J. Biol. Chem. 272 (3): 1456–60. PMID 8999814.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Liao W, Hong SH, Chan BH, et al. (1999). "APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family.". Biochem. Biophys. Res. Commun. 260 (2): 398–404. doi:10.1006/bbrc.1999.0925. PMID 10403781.
Anant S, Mukhopadhyay D, Sankaranand V, et al. (2001). "ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing.". Am. J. Physiol., Cell Physiol. 281 (6): C1904–16. PMID 11698249.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Prochnow C, Bransteitter R, Klein MG, et al. (2007). "The APOBEC-2 crystal structure and functional implications for the deaminase AID.". Nature 445 (7126): 447–51. doi:10.1038/nature05492. PMID 17187054.