APOBEC1

From Wikipedia, the free encyclopedia

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

Identifiers

APOBEC1; APOBEC-1; BEDP; CDAR1; HEPR

External IDs

OMIM: 600130 MGI: 103298 HomoloGene: 1243

Gene ontology
Molecular Function:	• RNA binding • cytidine deaminase activity • zinc ion binding • hydrolase activity • metal ion binding
Biological Process:	• mRNA editing • mRNA processing • lipid metabolic process • cytidine to uridine editing • lipoprotein metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001644 (mRNA)
NP_001635 (protein)

NM_031159 (mRNA)
NP_112436 (protein)

Location

Chr 12: 7.69 - 7.71 Mb

Chr 6: 122.54 - 122.57 Mb

Pubmed search

[1]

[2]

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1, also known as APOBEC1, is a human gene.^[1]

This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs.^[1]

[edit] References

^ ^a ^b Entrez Gene: APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1.

[edit] Further reading

Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.". Trends Genet. 19 (4): 207-16. PMID 12683974.
Harris RS, Liddament MT (2004). "Retroviral restriction by APOBEC proteins.". Nat. Rev. Immunol. 4 (11): 868-77. doi:10.1038/nri1489. PMID 15516966.
Espinosa R, Funahashi T, Hadjiagapiou C, et al. (1995). "Assignment of the gene encoding the human apolipoprotein B mRNA editing enzyme (APOBEC1) to chromosome 12p13.1.". Genomics 24 (2): 414-5. doi:10.1006/geno.1994.1645. PMID 7698776.
Navaratnam N, Bhattacharya S, Fujino T, et al. (1995). "Evolutionary origins of apoB mRNA editing: catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site.". Cell 81 (2): 187-95. PMID 7736571.
Lau PP, Zhu HJ, Baldini A, et al. (1994). "Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene.". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8522-6. PMID 8078915.
Hadjiagapiou C, Giannoni F, Funahashi T, et al. (1994). "Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein.". Nucleic Acids Res. 22 (10): 1874-9. PMID 8208612.
Morrison JR, Pászty C, Stevens ME, et al. (1996). "Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism.". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7154-9. PMID 8692961.
Lau PP, Zhu HJ, Nakamuta M, Chan L (1997). "Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing.". J. Biol. Chem. 272 (3): 1452-5. PMID 8999813.
Oka K, Kobayashi K, Sullivan M, et al. (1997). "Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice.". J. Biol. Chem. 272 (3): 1456-60. PMID 8999814.
Hirano K, Min J, Funahashi T, et al. (1997). "Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide.". J. Lipid Res. 38 (5): 847-59. PMID 9186903.
Fujino T, Navaratnam N, Scott J (1998). "Human apolipoprotein B RNA editing deaminase gene (APOBEC1).". Genomics 47 (2): 266-75. doi:10.1006/geno.1997.5110. PMID 9479499.
Mehta A, Kinter MT, Sherman NE, Driscoll DM (2000). "Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA.". Mol. Cell. Biol. 20 (5): 1846-54. PMID 10669759.
Lellek H, Kirsten R, Diehl I, et al. (2000). "Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex.". J. Biol. Chem. 275 (26): 19848-56. doi:10.1074/jbc.M001786200. PMID 10781591.
Blanc V, Navaratnam N, Henderson JO, et al. (2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing.". J. Biol. Chem. 276 (13): 10272-83. doi:10.1074/jbc.M006435200. PMID 11134005.
Lau PP, Chang BH, Chan L (2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome.". Biochem. Biophys. Res. Commun. 282 (4): 977-83. doi:10.1006/bbrc.2001.4679. PMID 11352648.
Anant S, Henderson JO, Mukhopadhyay D, et al. (2002). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor.". J. Biol. Chem. 276 (50): 47338-51. doi:10.1074/jbc.M104911200. PMID 11577082.
Lau PP, Villanueva H, Kobayashi K, et al. (2002). "A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing.". J. Biol. Chem. 276 (49): 46445-52. doi:10.1074/jbc.M109215200. PMID 11584023.
Anant S, Mukhopadhyay D, Sankaranand V, et al. (2001). "ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing.". Am. J. Physiol., Cell Physiol. 281 (6): C1904-16. PMID 11698249.
Mukhopadhyay D, Anant S, Lee RM, et al. (2002). "C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.". Am. J. Hum. Genet. 70 (1): 38-50. PMID 11727199.
Dance GS, Sowden MP, Cartegni L, et al. (2002). "Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing.". J. Biol. Chem. 277 (15): 12703-9. doi:10.1074/jbc.M111337200. PMID 11815617.