APOA5

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Apolipoprotein A-V
Identifiers
Symbol(s) APOA5; APOA-V; APOAV; MGC126836; MGC126838; RAP3
External IDs OMIM: 606368 MGI: 1913363 HomoloGene: 14197
Orthologs
Human Mouse
Entrez 116519 66113
Ensembl ENSG00000110243 ENSMUSG00000032079
Uniprot Q6Q788 Q8C7G5
Refseq NM_052968 (mRNA)
NP_443200 (protein)		 NM_080434 (mRNA)
NP_536682 (protein)
Location Chr 11: 116.17 - 116.17 Mb Chr 9: 46.02 - 46.02 Mb
Pubmed search [1] [2]

Apolipoprotein A-V, also known as APOA5, is a human gene.

The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of several lipoprotein fractions including VLDL, HDL, chylomicrons. It is believed that apoA-V affects lipoprotein metabolism by interacting with LDL-R gene family receptors.[1]

This gene uses alternate polyadenylation sites and is located proximal to the apolipoprotein gene cluster on chromosome 11q23.[2]

[edit] See also

[edit] References

  1. ^ ApoA-V LDL-Receptor Family Interactions.
  2. ^ Entrez Gene: APOA5 apolipoprotein A-V.

[edit] Further reading

  • Pennacchio LA, Rubin EM (2004). "Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice.". Arterioscler. Thromb. Vasc. Biol. 23 (4): 529-34. doi:10.1161/01.ATV.0000054194.78240.45. PMID 12615678. 
  • Jakel H, Nowak M, Helleboid-Chapman A, et al. (2006). "Is apolipoprotein A5 a novel regulator of triglyceride-rich lipoproteins?". Ann. Med. 38 (1): 2-10. doi:10.1080/07853890500407488. PMID 16448983. 
  • Calandra S, Priore Oliva C, Tarugi P, Bertolini S (2007). "APOA5 and triglyceride metabolism, lesson from human APOA5 deficiency.". Curr. Opin. Lipidol. 17 (2): 122-7. doi:10.1097/01.mol.0000217892.00618.54. PMID 16531747. 
  • Wong K, Ryan RO (2007). "Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation.". Curr. Opin. Lipidol. 18 (3): 319-24. doi:10.1097/MOL.0b013e328133856c. PMID 17495607. 
  • van der Vliet HN, Sammels MG, Leegwater AC, et al. (2002). "Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration.". J. Biol. Chem. 276 (48): 44512-20. doi:10.1074/jbc.M106888200. PMID 11577099. 
  • Pennacchio LA, Olivier M, Hubacek JA, et al. (2001). "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing.". Science 294 (5540): 169-73. doi:10.1126/science.1064852. PMID 11588264. 
  • Nabika T, Nasreen S, Kobayashi S, Masuda J (2003). "The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese.". Atherosclerosis 165 (2): 201-4. PMID 12417270. 
  • Pennacchio LA, Olivier M, Hubacek JA, et al. (2003). "Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels.". Hum. Mol. Genet. 11 (24): 3031-8. PMID 12417524. 
  • Talmud PJ, Hawe E, Martin S, et al. (2003). "Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.". Hum. Mol. Genet. 11 (24): 3039-46. PMID 12417525. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Vu-Dac N, Gervois P, Jakel H, et al. (2003). "Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators.". J. Biol. Chem. 278 (20): 17982-5. doi:10.1074/jbc.M212191200. PMID 12637506. 
  • Prieur X, Coste H, Rodriguez JC (2003). "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element.". J. Biol. Chem. 278 (28): 25468-80. doi:10.1074/jbc.M301302200. PMID 12709436. 
  • Weinberg RB, Cook VR, Beckstead JA, et al. (2003). "Structure and interfacial properties of human apolipoprotein A-V.". J. Biol. Chem. 278 (36): 34438-44. doi:10.1074/jbc.M303784200. PMID 12810715. 
  • Horínek A, Vráblík M, Ceska R, et al. (2003). "T-1131-->C polymorphism within the apolipoprotein AV gene in hypertriglyceridemic individuals.". Atherosclerosis 167 (2): 369-70. PMID 12818421. 
  • Beckstead JA, Oda MN, Martin DD, et al. (2003). "Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis.". Biochemistry 42 (31): 9416-23. doi:10.1021/bi034509t. PMID 12899628. 
  • Kao JT, Wen HC, Chien KL, et al. (2004). "A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia.". Hum. Mol. Genet. 12 (19): 2533-9. doi:10.1093/hmg/ddg255. PMID 12915450. 
  • Vrablík M, Horínek A, Ceska R, et al. (2003). "Ser19-->Trp polymorphism within the apolipoprotein AV gene in hypertriglyceridaemic people.". J. Med. Genet. 40 (8): e105. PMID 12920097. 
  • Lai CQ, Tai ES, Tan CE, et al. (2004). "The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore.". J. Lipid Res. 44 (12): 2365-73. doi:10.1194/jlr.M300251-JLR200. PMID 12951359. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
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Lipids: lipoprotein metabolism
General
Apolipoproteins
APOA (1, 2, 5) - APOB - APOC (1, 2, 3, 4) - APOD - APOE - APOH
Other
see also disorders