APOA4

From Wikipedia, the free encyclopedia

Apolipoprotein A-IV

Identifiers

APOA4; MGC142154; MGC142156

External IDs

OMIM: 107690 MGI: 88051 HomoloGene: 47927

Gene ontology
Molecular Function:	• lipid transporter activity • copper ion binding • lipid binding • antioxidant activity • low-density lipoprotein binding
Cellular Component:	• extracellular region • chylomicron
Biological Process:	• lipid metabolic process • lipid transport • response to lipid hydroperoxide • circulation • removal of superoxide radicals • regulation of cholesterol absorption • lipoprotein metabolic process • hydrogen peroxide catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000482 (mRNA)
NP_000473 (protein)

NM_007468 (mRNA)
NP_031494 (protein)

Location

Chr 11: 116.2 - 116.2 Mb

Chr 9: 45.99 - 45.99 Mb

Pubmed search

[1]

[2]

Apolipoprotein A-IV, also known as APOA4, is a human gene.

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.^[1]

[edit] References

^ Entrez Gene: APOA4 apolipoprotein A-IV.

[edit] Further reading

von Eckardstein A, Funke H, Schulte M, et al. (1992). "Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population.". Am. J. Hum. Genet. 50 (5): 1115–28. PMID 1349197.
Kamboh MI, Williams ER, Law JC, et al. (1993). "Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism.". Genet. Epidemiol. 9 (6): 379–88. doi:10.1002/gepi.1370090602. PMID 1487136.
Lohse P, Kindt MR, Rader DJ, Brewer HB (1991). "Three genetic variants of human plasma apolipoprotein A-IV. apoA-IV-1(Thr347----Ser), apoA-IV-0(Lys167----Glu,Gln360----His), and apoA-IV-3(Glu165----Lys).". J. Biol. Chem. 266 (21): 13513–8. PMID 1677358.
Tenkanen H, Koskinen P, Metso J, et al. (1992). "A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127.". Biochim. Biophys. Acta 1138 (1): 27–33. PMID 1737067.
Lohse P, Kindt MR, Rader DJ, Brewer HB (1990). "Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1.". J. Biol. Chem. 265 (21): 12734–9. PMID 1973689.
Tenkanen H, Lukka M, Jauhiainen M, et al. (1991). "The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360.". Arterioscler. Thromb. 11 (4): 851–6. PMID 2065039.
de Temmerman P, Visvikis S, Boerwinkle E, Siest G (1990). "Study of the sequence tagged site (STS) in the beginning of human apo A4 gene region.". Nucleic Acids Res. 18 (18): 5576. PMID 2216752.
Wei S, Rocchi M, Archidiacono N, et al. (1990). "Physical mapping of the human chromosome 11q23 region containing the ataxia-telangiectasia locus.". Cancer Genet. Cytogenet. 46 (1): 1–8. PMID 2331673.
Lohse P, Kindt MR, Rader DJ, Brewer HB (1990). "Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene.". J. Biol. Chem. 265 (17): 10061–4. PMID 2351649.
Yang CY, Gu ZW, Chong IS, et al. (1989). "The primary structure of human apolipoprotein A-IV.". Biochim. Biophys. Acta 1002 (2): 231–7. PMID 2930771.
Elshourbagy NA, Walker DW, Paik YK, et al. (1987). "Structure and expression of the human apolipoprotein A-IV gene.". J. Biol. Chem. 262 (17): 7973–81. PMID 3036793.
Elshourbagy NA, Walker DW, Boguski MS, et al. (1986). "The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III.". J. Biol. Chem. 261 (5): 1998–2002. PMID 3080432.
Karathanasis SK, Oettgen P, Haddad IA, Antonarakis SE (1986). "Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4).". Proc. Natl. Acad. Sci. U.S.A. 83 (22): 8457–61. PMID 3095836.
Bisgaier CL, Sachdev OP, Lee ES, et al. (1987). "Effect of lecithin:cholesterol acyltransferase on distribution of apolipoprotein A-IV among lipoproteins of human plasma.". J. Lipid Res. 28 (6): 693–703. PMID 3611972.
Karathanasis SK, Yunis I, Zannis VI (1986). "Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV.". Biochemistry 25 (13): 3962–70. PMID 3755616.
Karathanasis SK (1985). "Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes.". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6374–8. PMID 3931073.
Gordon JI, Bisgaier CL, Sims HF, et al. (1984). "Biosynthesis of human preapolipoprotein A-IV.". J. Biol. Chem. 259 (1): 468–74. PMID 6706947.
Menzel HJ, Dieplinger H, Sandholzer C, et al. (1995). "Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants.". Hum. Mutat. 5 (1): 58–65. doi:10.1002/humu.1380050108. PMID 7728150.
Duverger N, Tremp G, Caillaud JM, et al. (1996). "Protection against atherogenesis in mice mediated by human apolipoprotein A-IV.". Science 273 (5277): 966–8. PMID 8688083.
Deeb SS, Nevin DN, Iwasaki L, Brunzell JD (1997). "Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity.". Hum. Mutat. 8 (4): 319–25. doi:10.1002/(SICI)1098-1004(1996)8:4<319::AID-HUMU4>3.0.CO;2-2. PMID 8956036.