APOA2

From Wikipedia, the free encyclopedia

Apolipoprotein A-II

PDB rendering based on 1l6l.

Available structures: 1l6l, 2ou1

Identifiers

Symbol(s)

APOA2;

External IDs

OMIM: 107670 MGI: 88050 HomoloGene: 1242

Gene ontology
Molecular Function:	• lipid transporter activity • lipid binding • protein homodimerization activity • protein heterodimerization activity
Cellular Component:	• extracellular region
Biological Process:	• regulation of cytokine production • glucose metabolic process • lipid transport • response to glucose stimulus • regulation of cholesterol absorption • neutrophil activation • positive regulation of interleukin-8 biosynthetic process • negative regulation of lipoprotein metabolic process • negative regulation of lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001643 (mRNA)
NP_001634 (protein)

NM_013474 (mRNA)
NP_038502 (protein)

Location

Chr 1: 159.46 - 159.46 Mb

Chr 1: 173.06 - 173.06 Mb

Pubmed search

[1]

[2]

Apolipoprotein A-II, also known as APOA2, is a human gene.

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.^[1]

[edit] References

^ Entrez Gene: APOA2 apolipoprotein A-II.

[edit] Further reading

Blanco-Vaca F, Escolà-Gil JC, Martín-Campos JM, Julve J (2002). "Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein.". J. Lipid Res. 42 (11): 1727–39. PMID 11714842.
Kalopissis AD, Pastier D, Chambaz J (2003). "Apolipoprotein A-II: beyond genetic associations with lipid disorders and insulin resistance.". Curr. Opin. Lipidol. 14 (2): 165–72. doi:10.1097/01.mol.0000064047.08840.50. PMID 12642785.
Vollmer E, Brust J, Roessner A, et al. (1991). "Distribution patterns of apolipoproteins A1, A2, and B in the wall of atherosclerotic vessels.". Virchows Archiv. A, Pathological anatomy and histopathology 419 (2): 79–88. PMID 1908160.
Deeb SS, Takata K, Peng RL, et al. (1990). "A splice-junction mutation responsible for familial apolipoprotein A-II deficiency.". Am. J. Hum. Genet. 46 (4): 822–7. PMID 2107739.
Gordon JI, Sims HF, Edelstein C, et al. (1985). "Extracellular processing of proapolipoprotein A-II in Hep G2 cell cultures is mediated by a 54-kDa protease immunologically related to cathepsin B.". J. Biol. Chem. 260 (27): 14824–31. PMID 2414299.
Tsao YK, Wei CF, Robberson DL, et al. (1986). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes.". J. Biol. Chem. 260 (28): 15222–31. PMID 2415515.
Lackner KJ, Law SW, Brewer HB (1985). "The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization.". Nucleic Acids Res. 13 (12): 4597–608. PMID 2989800.
Knott TJ, Wallis SC, Robertson ME, et al. (1985). "The human apolipoprotein AII gene: structural organization and sites of expression.". Nucleic Acids Res. 13 (17): 6387–98. PMID 2995928.
Chan L, Moore MN, Tsao YK (1986). "Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA.". Meth. Enzymol. 128: 745–52. PMID 3088392.
Middleton-Price HR, van den Berghe JA, Scott J, et al. (1988). "Regional chromosomal localisation of APOA2 to 1q21-1q23.". Hum. Genet. 79 (3): 283–5. PMID 3136074.
Shelley CS, Sharpe CR, Baralle FE, Shoulders CC (1986). "Comparison of the human apolipoprotein genes. Apo AII presents a unique functional intron-exon junction.". J. Mol. Biol. 186 (1): 43–51. PMID 3935800.
Brewer HB, Lux SE, Ronan R, John KM (1972). "Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex.". Proc. Natl. Acad. Sci. U.S.A. 69 (5): 1304–8. PMID 4338591.
Lux SE, John KM, Ronan R, Brewer HB (1973). "Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein.". J. Biol. Chem. 247 (23): 7519–27. PMID 4344225.
Moore MN, Kao FT, Tsao YK, Chan L (1984). "Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1.". Biochem. Biophys. Res. Commun. 123 (1): 1–7. PMID 6089788.
Lackner KJ, Law SW, Brewer HB (1984). "Human apolipoprotein A-II: complete nucleic acid sequence of preproapo A-II.". FEBS Lett. 175 (1): 159–64. PMID 6090207.
Gordon JI, Budelier KA, Sims HF, et al. (1984). "Biosynthesis of human preproapolipoprotein A-II.". J. Biol. Chem. 258 (22): 14054–9. PMID 6315718.
Sharpe CR, Sidoli A, Shelley CS, et al. (1984). "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.". Nucleic Acids Res. 12 (9): 3917–32. PMID 6328445.
Stoffel W, Krüger E, Deutzmann R (1983). "Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products.". Hoppe-Seyler's Z. Physiol. Chem. 364 (3): 227–37. PMID 6407957.
Knott TJ, Priestley LM, Urdea M, Scott J (1984). "Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII.". Biochem. Biophys. Res. Commun. 120 (3): 734–40. PMID 6428397.
Lackner KJ, Law SW, Brewer HB, et al. (1984). "The human apolipoprotein A-II gene is located on chromosome 1.". Biochem. Biophys. Res. Commun. 122 (3): 877–83. PMID 6433912.