APBB2

From Wikipedia, the free encyclopedia

Amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)

PDB rendering based on 1wgu.

Available structures: 1wgu

Identifiers

Symbol(s)

APBB2; FE65L; FE65L1; MGC35575

External IDs

OMIM: 602710 MGI: 108405 HomoloGene: 32079

Gene ontology
Molecular Function:	• beta-amyloid binding • transcription factor binding • histone acetyltransferase binding
Cellular Component:	• nucleus • cytoplasm • membrane • lamellipodium • growth cone • synapse
Biological Process:	• neuron migration • cell cycle arrest • intracellular signaling cascade • axon guidance • actin filament-based movement • extracellular matrix organization and biogenesis • negative regulation of cell growth • positive regulation of apoptosis • negative regulation of apoptosis • regulation of transcription • negative regulation of S phase of mitotic cell cycle • protein stabilization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_173075 (mRNA)
NP_775098 (protein)

NM_009686 (mRNA)
NP_033816 (protein)

Location

Chr 4: 40.51 - 40.91 Mb

Chr 5: 66.58 - 66.9 Mb

Pubmed search

[1]

[2]

Amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like), also known as APBB2, is a human gene.^[1]

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.^[1]

[edit] References

^ ^a ^b Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like).

[edit] Further reading

Guénette SY, Chen J, Jondro PD, Tanzi RE (1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10832–7. PMID 8855266.
McLoughlin DM, Miller CC (1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system.". FEBS Lett. 397 (2-3): 197–200. PMID 8955346.
Blanco G, Irving NG, Brown SD, et al. (1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein.". Mamm. Genome 9 (6): 473–5. PMID 9585438.
Bruni P, Minopoli G, Brancaccio T, et al. (2002). "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression.". J. Biol. Chem. 277 (38): 35481–8. doi:10.1074/jbc.M205227200. PMID 12089154.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chang Y, Tesco G, Jeong WJ, et al. (2004). "Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.". J. Biol. Chem. 278 (51): 51100–7. doi:10.1074/jbc.M309561200. PMID 14527950.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Li Y, Hollingworth P, Moore P, et al. (2006). "Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease.". Hum. Mutat. 25 (3): 270–7. doi:10.1002/humu.20138. PMID 15714520.
Lange A, Thon L, Mathieu S, Adam D (2005). "The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor.". Biochem. Biophys. Res. Commun. 335 (2): 575–83. doi:10.1016/j.bbrc.2005.07.125. PMID 16083851.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hong Q, Hsu LJ, Schultz L, et al. (2007). "Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response.". BMC Mol. Biol. 8: 50. doi:10.1186/1471-2199-8-50. PMID 17567906.