AP4M1

From Wikipedia, the free encyclopedia

Adaptor-related protein complex 4, mu 1 subunit

Identifiers

AP4M1; MU-4; MU-ARP2

External IDs

OMIM: 602296 MGI: 1337063 HomoloGene: 3467

Gene ontology
Molecular Function:	• transporter activity
Cellular Component:	• Golgi trans cisterna • coated pit • AP-type membrane coat adaptor complex • clathrin vesicle coat • coated vesicle membrane
Biological Process:	• transport • intracellular protein transport • vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004722 (mRNA)
NP_004713 (protein)

NM_021392 (mRNA)
NP_067367 (protein)

Location

Chr 7: 99.54 - 99.55 Mb

Chr 5: 138.4 - 138.41 Mb

Pubmed search

[1]

[2]

Adaptor-related protein complex 4, mu 1 subunit, also known as AP4M1, is a human gene.^[1]

This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system.^[1]

[edit] References

^ ^a ^b Entrez Gene: AP4M1 adaptor-related protein complex 4, mu 1 subunit.

[edit] Further reading

Wang X, Kilimann MW (1997). "Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2.". FEBS Lett. 402 (1): 57-61. PMID 9013859.
Stephens DJ, Banting G (1998). "Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120.". Biochem. J. 335 ( Pt 3): 567-72. PMID 9794796.
Dell'Angelica EC, Mullins C, Bonifacino JS (1999). "AP-4, a novel protein complex related to clathrin adaptors.". J. Biol. Chem. 274 (11): 7278-85. PMID 10066790.
Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex.". Mol. Biol. Cell 10 (8): 2787-802. PMID 10436028.
Aguilar RC, Boehm M, Gorshkova I, et al. (2001). "Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4.". J. Biol. Chem. 276 (16): 13145-52. doi:10.1074/jbc.M010591200. PMID 11139587.
Boehm M, Aguilar RC, Bonifacino JS (2002). "Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs).". EMBO J. 20 (22): 6265-76. doi:10.1093/emboj/20.22.6265. PMID 11707398.
Simmen T, Höning S, Icking A, et al. (2002). "AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells.". Nat. Cell Biol. 4 (2): 154-9. doi:10.1038/ncb745. PMID 11802162.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.