AP2A2

From Wikipedia, the free encyclopedia

Adaptor-related protein complex 2, alpha 2 subunit

PDB rendering based on 1b9k.

Available structures: 1b9k, 1gw5, 1ky6, 1ky7, 1kyd, 1kyf, 1kyu, 1qtp, 1qts, 1w80

Identifiers

Symbol(s)

AP2A2; ADTAB; CLAPA2; HIP9; HYPJ

External IDs

OMIM: 607242 MGI: 101920 HomoloGene: 5335

Gene ontology
Molecular Function:	• structural molecule activity • binding • lipid binding
Cellular Component:	• coated pit • membrane coat • AP-2 adaptor complex • clathrin coat of trans-Golgi network vesicle
Biological Process:	• protein complex assembly • intracellular protein transport • endocytosis • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012305 (mRNA)
NP_036437 (protein)

NM_007459 (mRNA)
NP_031485 (protein)

Location

Chr 11: 0.92 - 1 Mb

Chr 7: 141.41 - 141.48 Mb

Pubmed search

[1]

[2]

Adaptor-related protein complex 2, alpha 2 subunit, also known as AP2A2, is a human gene.^[1]

[edit] References

^ Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit.

[edit] Further reading

Kirchhausen T (2000). "Clathrin.". Annu. Rev. Biochem. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Robinson MS (1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).". J. Cell Biol. 108 (3): 833–42. PMID 2564002.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
David C, McPherson PS, Mundigl O, de Camilli P (1996). "A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals.". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 331–5. PMID 8552632.
Okabayashi Y, Sugimoto Y, Totty NF, et al. (1996). "Interaction of Shc with adaptor protein adaptins.". J. Biol. Chem. 271 (9): 5265–9. PMID 8617812.
Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N (1996). "The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein.". J. Biol. Chem. 271 (20): 12111–6. PMID 8662627.
van Delft S, Schumacher C, Hage W, et al. (1997). "Association and colocalization of Eps15 with adaptor protein-2 and clathrin.". J. Cell Biol. 136 (4): 811–21. PMID 9049247.
Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform.". J. Biol. Chem. 272 (26): 16700–6. PMID 9195986.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Faber PW, Barnes GT, Srinidhi J, et al. (1998). "Huntingtin interacts with a family of WW domain proteins.". Hum. Mol. Genet. 7 (9): 1463–74. PMID 9700202.
Chen H, Fre S, Slepnev VI, et al. (1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.". Nature 394 (6695): 793–7. doi:10.1038/29555. PMID 9723620.
Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.". J. Virol. 73 (2): 1350–61. PMID 9882340.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. PMID 10048485.
Traub LM, Downs MA, Westrich JL, Fremont DH (1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly.". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 8907–12. PMID 10430869.
Page LJ, Sowerby PJ, Lui WW, Robinson MS (1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin.". J. Cell Biol. 146 (5): 993–1004. PMID 10477754.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806.
Slepnev VI, Ochoa GC, Butler MH, De Camilli P (2000). "Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites.". J. Biol. Chem. 275 (23): 17583–9. doi:10.1074/jbc.M910430199. PMID 10748223.
Jullien-Flores V, Mahé Y, Mirey G, et al. (2000). "RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis.". J. Cell. Sci. 113 ( Pt 16): 2837–44. PMID 10910768.