AP1M2

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Adaptor-related protein complex 1, mu 2 subunit
Identifiers
Symbol(s) AP1M2; HSMU1B; MU-1B; MU1B
External IDs OMIM: 607309 MGI: 1336974 HomoloGene: 55906
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10053 11768
Ensembl ENSG00000129354 ENSMUSG00000003309
Uniprot Q9Y6Q5 Q8C9K8
Refseq NM_005498 (mRNA)
NP_005489 (protein)		 NM_009678 (mRNA)
NP_033808 (protein)
Location Chr 19: 10.54 - 10.56 Mb Chr 9: 21.05 - 21.06 Mb
Pubmed search [1] [2]

Adaptor-related protein complex 1, mu 2 subunit, also known as AP1M2, is a human gene.[1]

This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals.[1]

[edit] References

  1. ^ a b Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit.

[edit] Further reading

  • Hirst J, Robinson MS (1998). "Clathrin and adaptors.". Biochim. Biophys. Acta 1404 (1-2): 173–93. PMID 9714795. 
  • Ohno H, Stewart J, Fournier MC, et al. (1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins.". Science 269 (5232): 1872–5. PMID 7569928. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Seaman MN, Sowerby PJ, Robinson MS (1996). "Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network.". J. Biol. Chem. 271 (41): 25446–51. PMID 8810314. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Stephens DJ, Banting G (1998). "Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120.". Biochem. J. 335 ( Pt 3): 567–72. PMID 9794796. 
  • Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.". J. Virol. 73 (2): 1350–61. PMID 9882340. 
  • Ohno H, Tomemori T, Nakatsu F, et al. (1999). "Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells.". FEBS Lett. 449 (2-3): 215–20. PMID 10338135. 
  • Fölsch H, Ohno H, Bonifacino JS, Mellman I (1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells.". Cell 99 (2): 189–98. PMID 10535737. 
  • Nakatsu F, Kadohira T, Gilbert DJ, et al. (2000). "Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2).". Cytogenet. Cell Genet. 87 (1-2): 53–8. PMID 10640811. 
  • Umeda A, Meyerholz A, Ungewickell E (2000). "Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation.". Eur. J. Cell Biol. 79 (5): 336–42. PMID 10887964. 
  • Fölsch H, Pypaert M, Schu P, Mellman I (2001). "Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells.". J. Cell Biol. 152 (3): 595–606. PMID 11157985. 
  • Wyss S, Berlioz-Torrent C, Boge M, et al. (2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter].". J. Virol. 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMID 11222723. 
  • Ohka S, Ohno H, Tohyama K, Nomoto A (2001). "Basolateral sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in polarized epithelial cells.". Biochem. Biophys. Res. Commun. 287 (4): 941–8. doi:10.1006/bbrc.2001.5660. PMID 11573956. 
  • Korolchuk VI, Banting G (2003). "CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles.". Traffic 3 (6): 428–39. PMID 12010461. 
  • Collins BM, McCoy AJ, Kent HM, et al. (2002). "Molecular architecture and functional model of the endocytic AP2 complex.". Cell 109 (4): 523–35. PMID 12086608. 
  • Sugimoto H, Sugahara M, Fölsch H, et al. (2003). "Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells.". Mol. Biol. Cell 13 (7): 2374–82. doi:10.1091/mbc.E01-10-0096. PMID 12134076. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
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