AP1GBP1

From Wikipedia, the free encyclopedia

AP1 gamma subunit binding protein 1

Identifiers

AP1GBP1; MGC104959; SYNG

External IDs

OMIM: 607291 MGI: 1354742 HomoloGene: 50953

Gene ontology
Molecular Function:	• calcium ion binding
Cellular Component:	• cytoplasm • Golgi apparatus • membrane • AP-1 adaptor complex
Biological Process:	• intracellular protein transport • endocytosis

Orthologs

Human

Mouse

Refseq

NM_007247 (mRNA)
NP_009178 (protein)

NM_194341 (mRNA)
NP_919322 (protein)

Location

Chr 17: 32.95 - 33.04 Mb

Chr 11: 83.78 - 83.86 Mb

Pubmed search

[1]

[2]

AP1 gamma subunit binding protein 1, also known as AP1GBP1, is a human gene.^[1]

This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: AP1GBP1 AP1 gamma subunit binding protein 1.

[edit] Further reading

Peyrard M, Parveneh S, Lagercrantz S, et al. (1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG).". Genomics 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655.
Page LJ, Sowerby PJ, Lui WW, Robinson MS (1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin.". J. Cell Biol. 146 (5): 993–1004. PMID 10477754.
Hirst J, Lui WW, Bright NA, et al. (2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome.". J. Cell Biol. 149 (1): 67–80. PMID 10747088.
Fernández-Chacón R, Achiriloaie M, Janz R, et al. (2000). "SCAMP1 function in endocytosis.". J. Biol. Chem. 275 (17): 12752–6. PMID 10777571.
Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin.". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
Nogi T, Shiba Y, Kawasaki M, et al. (2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain.". Nat. Struct. Biol. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876.
Kent HM, McMahon HT, Evans PR, et al. (2003). "Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin.". Structure 10 (8): 1139–48. PMID 12176391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mills IG, Praefcke GJ, Vallis Y, et al. (2003). "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking.". J. Cell Biol. 160 (2): 213–22. doi:10.1083/jcb.200208023. PMID 12538641.
Lui WW, Collins BM, Hirst J, et al. (2004). "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin.". Mol. Biol. Cell 14 (6): 2385–98. doi:10.1091/mbc.E02-11-0735. PMID 12808037.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hirst J, Borner GH, Harbour M, Robinson MS (2005). "The aftiphilin/p200/gamma-synergin complex.". Mol. Biol. Cell 16 (5): 2554–65. doi:10.1091/mbc.E04-12-1077. PMID 15758025.
Theos AC, Tenza D, Martina JA, et al. (2006). "Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes.". Mol. Biol. Cell 16 (11): 5356–72. doi:10.1091/mbc.E05-07-0626. PMID 16162817.