AP1G1

From Wikipedia, the free encyclopedia

Adaptor-related protein complex 1, gamma 1 subunit

PDB rendering based on 1gyu.

Available structures: 1gyu, 1gyv, 1gyw, 1iu1, 1w63, 2a7b

Identifiers

Symbol(s)

AP1G1; ADTG; CLAPG1; MGC18255

External IDs

OMIM: 603533 MGI: 101919 HomoloGene: 47995

Gene ontology
Molecular Function:	• transporter activity • binding • protein binding
Cellular Component:	• cytoplasm • Golgi apparatus • coated pit • AP-type membrane coat adaptor complex • clathrin coat of trans-Golgi network vesicle • clathrin-coated vesicle • perinuclear region of cytoplasm
Biological Process:	• protein complex assembly • intracellular protein transport • endocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001030007 (mRNA)
NP_001025178 (protein)

XM_001000444 (mRNA)
XP_001000444 (protein)

Location

Chr 16: 70.32 - 70.4 Mb

Chr 8: 112.67 - 112.85 Mb

Pubmed search

[1]

[2]

Adaptor-related protein complex 1, gamma 1 subunit, also known as AP1G1, is a human gene.

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Peyrard M, Parveneh S, Lagercrantz S, et al. (1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG).". Genomics 50 (2): 275-80. doi:10.1006/geno.1998.5289. PMID 9653655.
Takatsu H, Sakurai M, Shin HW, et al. (1998). "Identification and characterization of novel clathrin adaptor-related proteins.". J. Biol. Chem. 273 (38): 24693-700. PMID 9733768.
Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.". J. Virol. 73 (2): 1350-61. PMID 9882340.
Page LJ, Sowerby PJ, Lui WW, Robinson MS (1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin.". J. Cell Biol. 146 (5): 993-1004. PMID 10477754.
Fölsch H, Ohno H, Bonifacino JS, Mellman I (1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells.". Cell 99 (2): 189-98. PMID 10535737.
Hirst J, Lui WW, Bright NA, et al. (2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome.". J. Cell Biol. 149 (1): 67-80. PMID 10747088.
Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin.". Biochem. Biophys. Res. Commun. 271 (3): 719-25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
Nakagawa T, Setou M, Seog D, et al. (2001). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex.". Cell 103 (4): 569-81. PMID 11106728.
Wyss S, Berlioz-Torrent C, Boge M, et al. (2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter].". J. Virol. 75 (6): 2982-92. doi:10.1128/JVI.75.6.2982-2992.2001. PMID 11222723.
Crump CM, Xiang Y, Thomas L, et al. (2001). "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.". EMBO J. 20 (9): 2191-201. doi:10.1093/emboj/20.9.2191. PMID 11331585.
Takatsu H, Futatsumori M, Yoshino K, et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.". Biochem. Biophys. Res. Commun. 284 (4): 1083-9. doi:10.1006/bbrc.2001.5081. PMID 11409905.
Orzech E, Livshits L, Leyt J, et al. (2001). "Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins.". J. Biol. Chem. 276 (33): 31340-8. doi:10.1074/jbc.M101054200. PMID 11418592.
Doray B, Kornfeld S (2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly.". Mol. Biol. Cell 12 (7): 1925-35. PMID 11451993.
Shiba Y, Takatsu H, Shin HW, Nakayama K (2002). "Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain.". J. Biochem. 131 (3): 327-36. PMID 11872161.
Austin C, Boehm M, Tooze SA (2002). "Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3.". Biochemistry 41 (14): 4669-77. PMID 11926829.
Eiraku M, Hirata Y, Takeshima H, et al. (2002). "Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.". J. Biol. Chem. 277 (28): 25400-7. doi:10.1074/jbc.M110793200. PMID 11950833.
Nogi T, Shiba Y, Kawasaki M, et al. (2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain.". Nat. Struct. Biol. 9 (7): 527-31. doi:10.1038/nsb808. PMID 12042876.
Kalthoff C, Groos S, Kohl R, et al. (2003). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi.". Mol. Biol. Cell 13 (11): 4060-73. doi:10.1091/mbc.E02-03-0171. PMID 12429846.