ANXA9

From Wikipedia, the free encyclopedia

Annexin A9

Identifiers

External IDs

OMIM: 603319 MGI: 1923711 HomoloGene: 2643

Gene ontology
Molecular Function:	• phosphatidylserine binding • calcium ion binding • calcium-dependent phospholipid binding • acetylcholine receptor activity • protein homodimerization activity
Cellular Component:	• cytosol • cell surface
Biological Process:	• cell-cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003568 (mRNA)
NP_003559 (protein)

NM_023628 (mRNA)
NP_076117 (protein)

Location

Chr 1: 149.22 - 149.23 Mb

Chr 3: 95.38 - 95.39 Mb

Pubmed search

[1]

[2]

Annexin A9, also known as ANXA9, is a human gene.^[1]

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.^[1]

[edit] References

^ ^a ^b Entrez Gene: ANXA9 annexin A9.

[edit] Further reading

Benz J, Hofmann A (1997). "Annexins: from structure to function.". Biol. Chem. 378 (3-4): 177–83. PMID 9165068.
Morgan RO, Fernandez MP (1998). "Expression profile and structural divergence of novel human annexin 31.". FEBS Lett. 434 (3): 300–4. PMID 9742942.
Morgan RO, Bell DW, Testa JR, Fernandez MP (1999). "Human annexin 31 genetic mapping and origin.". Gene 227 (1): 33–8. PMID 9931420.
Nguyen VT, Ndoye A, Grando SA (2000). "Pemphigus vulgaris antibody identifies pemphaxin. A novel keratinocyte annexin-like molecule binding acetylcholine.". J. Biol. Chem. 275 (38): 29466–76. doi:10.1074/jbc.M003174200. PMID 10899159.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Goebeler V, Ruhe D, Gerke V, Rescher U (2003). "Atypical properties displayed by annexin A9, a novel member of the annexin family of Ca(2+) and lipid binding proteins.". FEBS Lett. 546 (2-3): 359–64. PMID 12832069.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.