ANXA8L2

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Annexin A8
PDB rendering based on 1w3w.
Available structures: 1w3w, 1w45
Identifiers
Symbol(s) ANXA8; ANX8; ANXA8L2; FLJ32754; VAC beta
External IDs OMIM: 602396 HomoloGene: 88650
Orthologs
Human Mouse
Entrez 244 n/a


Refseq NM_001630 (mRNA)
NP_001621 (protein)		 n/a (mRNA)
n/a (protein)
Pubmed search [1] n/a

Annexin A8, also known as ANXA8, is a human gene.[1]

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.[1]

[edit] References

  1. ^ a b Entrez Gene: ANXA8 annexin A8.

[edit] Further reading

  • Gerke V, Moss SE (2002). "Annexins: from structure to function.". Physiol. Rev. 82 (2): 331–71. doi:10.1152/physrev.00030.2001. PMID 11917092. 
  • Gerke V, Creutz CE, Moss SE (2005). "Annexins: linking Ca2+ signalling to membrane dynamics.". Nat. Rev. Mol. Cell Biol. 6 (6): 449–61. doi:10.1038/nrm1661. PMID 15928709. 
  • Chang KS, Wang G, Freireich EJ, et al. (1992). "Specific expression of the annexin VIII gene in acute promyelocytic leukemia.". Blood 79 (7): 1802–10. PMID 1313714. 
  • Chambers JA, Gardner E, Hauptmann R, et al. (1993). "TaqI polymorphisms at the annexin VIII locus (ANX8).". Hum. Mol. Genet. 1 (7): 550. PMID 1364010. 
  • Hauptmann R, Maurer-Fogy I, Krystek E, et al. (1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha.". Eur. J. Biochem. 185 (1): 63–71. PMID 2530088. 
  • Sarkar A, Yang P, Fan YH, et al. (1994). "Regulation of the expression of annexin VIII in acute promyelocytic leukemia.". Blood 84 (1): 279–86. PMID 8018923. 
  • Reutelingsperger CP, van Heerde W, Hauptmann R, et al. (1994). "Differential tissue expression of Annexin VIII in human.". FEBS Lett. 349 (1): 120–4. PMID 8045287. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Stein T, Price KN, Morris JS, et al. (2006). "Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.". Clin. Cancer Res. 11 (19 Pt 1): 6872–9. doi:10.1158/1078-0432.CCR-05-0547. PMID 16203777. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Goebeler V, Ruhe D, Gerke V, Rescher U (2006). "Annexin A8 displays unique phospholipid and F-actin binding properties.". FEBS Lett. 580 (10): 2430–4. doi:10.1016/j.febslet.2006.03.076. PMID 16638567. 
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