Talk:Anthrax toxin
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Article Grading: The following comments were left by the quality and importance raters: (edit · history · refresh · how to use this template) I've been doing a review of Protective-Antigen related work, and this article suggests that the pore maintains contact with the cellular receptor after insertion. There is evidence suggesting otherwise using immunoprecipitation assays which show receptor release associated with a pH drop (Fig. 2 in Rainey, et all PNAS (2005) Vol. 102, No.37), indicating that the idea of a cellular receptor 'supporting' the pore for insertion may be inaccurate, since pore insertion is observed in lipid bilayers in the absence of cellular receptors. I'm genuinely curious about what role(s) the ATR may play besides localizing PA83 to the membrane for removal of the 20 kDa fragment prior to oligomerization, so any more info or insight you have would be great. Thanks! AshleyP |
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[edit] Copyright assertation
I am a doctoral student and after a year and a half of researching the topic and after several drafts (which were used as term papers for my college courses), I wrote this article. I have a ton of figures for it, but the quality of some of them need to be improved. I've been swamped with my classes, work and my family, so it might a few months before I finish fixing the images and wikifying the article (I also recently noticed that many of my links to my references disappered when I was copying from my word perfect document, so I need to fix that too). Also I haven't had the time to figure out how to post new images. I'll try to update the article asap. I hold the copyright of the original posting of this article (yes, I posted a lot in one day... because I wrote it first in a word processor) and release it under the GFDL by posting it to wikipedia. If anyone has questions as to whether this is truly my original work, please contact me and I can discuss it with you. I once again verify that this is my original work and none of it has been plegorized from any other source. --Nate 19:16, 10 November 2006 (UTC)
[edit] References
I began trying to reformat the references, but now I realize I'm not sure exactly where the references go. I reformatted the first 6 and just replaced the number in parentheses with a < ref > tag. I couldn't find reference #7 anywhere in the text. Without reading all the articles referenced, I don't think I can justify continuing to reformat. However, this is an excellent article and very well written. Good luck with your PhD work! Ramin Herati (Sedmic) 16:10, 17 December 2006 (UTC)
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- I too got lost in amongst the references after wikifying the first two sections. As a minor aside, I've worked in the bacterial toxin field in the past, and I have never heard the system of anthrax virulence factors referred to as a singular 'anthrax toxin'. The two A components of a binary toxin sharing a single B component is unique (i think)... but I've never heard anyone refer to Anthrax toxin. Possibly rename the page to Anthrax virulence factors (a bit wordy) or maybe Anthrax toxins.
Good work though. Bassophile 14:28, 15 January 2007 (UTC)
The correct name of the toxin is 'anthrax toxin.' Don't confuse the fact that 3 proteins are involved. Lethal toxin is a mixture of LF and PA. Anthrax toxin is a mixture of EF, LF and PA. None of these proteins on their own are toxic to cells. bakrantz
