Antianalgesia

From Wikipedia, the free encyclopedia

Antianalgesia is the ability of some endogenous chemicals (notably cholecystokinin and neuropeptide Y) to counter the effects of exogenous analgesics (such as morphine) or endogenous pain inhibiting neurotransmitters/modulators, such as the endogenous opioids.[1] A learned form can be established using methods similar to the learning principle of conditioned inhibition, and has been demonstrated in rats.

[edit] References

  1. ^ Wiertelak, EP; Maier, SF and Watkins, LR (8 May 1992). "Cholecystokinin antianalgesia: safety cues abolish morphine analgesia" (abstract). Science 256 (5058): 830–833. doi:10.1126/science.1589765.