Anthranilate phosphoribosyltransferase

From Wikipedia, the free encyclopedia

In enzymology, an anthranilate phosphoribosyltransferase (EC 2.4.2.18) is an enzyme that catalyzes the chemical reaction

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate $\rightleftharpoons$ anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate

Thus, the two substrates of this enzyme are N-(5-phospho-D-ribosyl)-anthranilate and diphosphate, whereas its two products are anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase. Other names in common use include phosphoribosyl-anthranilate pyrophosphorylase, PRT, anthranilate 5-phosphoribosylpyrophosphate, phosphoribosyltransferase, anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase, phosphoribosylanthranilate pyrophosphorylase, phosphoribosylanthranilate transferase, and anthranilate-PP-ribose-P phosphoribosyltransferase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and two-component system - general.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1GXB, 1KGZ, 1KHD, 1O17, 1V8G, 1VQU, 1ZVW, 1ZXY, 1ZYK, 2BPQ, 2ELC, and 2GVQ.

[edit] References

IUBMB entry for 2.4.2.18
BRENDA references for 2.4.2.18 (Recommended.)
PubMed references for 2.4.2.18
PubMed Central references for 2.4.2.18
Google Scholar references for 2.4.2.18
Creighton TE and Yanofsky C (1970). "Chorismate to tryptophan (Escherichia coli) - Anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan synthetase". Methods Enzymol. 17A: 365–380.
Kung CC, Huang WN, Huang YC, Yeh KC (2006). "Proteomic survey of copper-binding proteins in Arabidopsis roots by immobilized metal affinity chromatography and mass spectrometry". Proteomics. 6: 2746–58. doi:10.1002/pmic.200500108. PMID 16526091.
Ito J, Yanofsky C (1969). "Anthranilate synthetase, an enzyme specified by the tryptophan operon of Escherichia coli: Comparative studies on the complex and the subunits". J. Bacteriol. 97: 734–42. PMID 4886290.
Wegman J, DeMoss JA (1965). "The enzymatic conversion of anthranilate to indolylglycerol phosphate in Neurospora crassa". J. Biol. Chem. 240: 3781–8. PMID 5842052.