Anthranilate-CoA ligase

From Wikipedia, the free encyclopedia

In enzymology, an anthranilate-CoA ligase (EC 6.2.1.32) is an enzyme that catalyzes the chemical reaction

ATP + anthranilate + CoA AMP + diphosphate + anthranilyl-CoA

The 3 substrates of this enzyme are ATP, anthranilate, and CoA, whereas its 3 products are AMP, diphosphate, and anthranilyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is anthranilate:CoA ligase (AMP-forming). Other names in common use include anthraniloyl coenzyme A synthetase, 2-aminobenzoate-CoA ligase, 2-aminobenzoate-coenzyme A ligase, and 2-aminobenzoate coenzyme A ligase. This enzyme participates in 3 metabolic pathways: carbazole degradation, benzoate degradation via coa ligation, and acridone alkaloid biosynthesis.

[edit] References

• IUBMB entry for 6.2.1.32
• BRENDA references for 6.2.1.32 (Recommended.)
• PubMed references for 6.2.1.32
• PubMed Central references for 6.2.1.32
• Google Scholar references for 6.2.1.32
• Altenschmidt U, Eckerskorn C, Fuchs G (1990). "Evidence that enzymes of a novel aerobic 2-amino-benzoate metabolism in denitrifying Pseudomonas are coded on a small plasmid". Eur. J. Biochem. 194: 647–53. doi:10.1111/j.1432-1033.1990.tb15664.x. PMID 2176602. 

[edit] External links

The CAS registry number for this enzyme class is 112692-58-7.

• IUBMB entry for 6.2.1.32

• KEGG entry for 6.2.1.32

• BRENDA entry for 6.2.1.32

• NiceZyme view of 6.2.1.32

• EC2PDB: PDB structures for 6.2.1.32

• PRIAM entry for 6.2.1.32

• PUMA2 entry for 6.2.1.32

• IntEnz: Integrated Enzyme entry for 6.2.1.32

• MetaCyc entry for 6.2.1.32

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018860: anthranilate-CoA ligase

• AMIGO entry for GO code 0018860: anthranilate-CoA ligase