Anthocyanidin 3-O-glucosyltransferase

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In enzymology, an anthocyanidin 3-O-glucosyltransferase (EC 2.4.1.115) is an enzyme that catalyzes the chemical reaction

UDP-D-glucose + an anthocyanidin $\rightleftharpoons$ UDP + an anthocyanidin-3-O-beta-D-glucoside

Thus, the two substrates of this enzyme are UDP-D-glucose and anthocyanidin, whereas its two products are UDP and anthocyanidin-3-O-beta-D-glucoside.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase. Other names in common use include uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase, UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase, UDP-glucose:cyanidin-3-O-glucosyltransferase, UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase, and 3-GT. This enzyme participates in flavonoid biosynthesis.

[edit] References

IUBMB entry for 2.4.1.115
BRENDA references for 2.4.1.115 (Recommended.)
PubMed references for 2.4.1.115
PubMed Central references for 2.4.1.115
Google Scholar references for 2.4.1.115
Kamsteeg J, van Brederode J, van Nigtevecht G (1978). "Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica)". Biochem. Genet. 16: 1045–58. doi:10.1007/BF00484525. PMID 751640.
Ford CM, Boss PK, Hoj PB (1998). "Cloning and characterization of Vitis vinifera UDP-glucose:flavonoid 3-O-glucosyltransferase, a homologue of the enzyme encoded by the maize Bronze-1 locus that may primarily serve to glucosylate anthocyanidins in vivo". J. Biol. Chem. 273: 9224–33. doi:10.1074/jbc.273.15.9224. PMID 9535914.
Nakajima J, Tanaka Y, Yamazaki M, Saito K (2001). "Reaction mechanism from leucoanthocyanidin to anthocyanidin 3-glucoside, a key reaction for coloring in anthocyanin biosynthesis". J. Biol. Chem. 276: 25797–803. doi:10.1074/jbc.M100744200. PMID 11316805.