ANTXR2

From Wikipedia, the free encyclopedia

Anthrax toxin receptor 2

PDB rendering based on 1sht.

Available structures: 1sht, 1shu, 1t6b, 1tzn

Identifiers

Symbol(s)

ANTXR2; CMG-2; CMG2; FLJ31074; ISH; JHF; MGC111533; MGC45856

External IDs

OMIM: 608041 MGI: 1919164 HomoloGene: 43236

Gene ontology
Molecular Function:	• receptor activity • protein binding • metal ion binding
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane

Orthologs

Human

Mouse

Refseq

NM_058172 (mRNA)
NP_477520 (protein)

NM_133738 (mRNA)
NP_598499 (protein)

Location

Chr 4: 81.12 - 81.21 Mb

Chr 5: 98.18 - 98.27 Mb

Pubmed search

[1]

[2]

Anthrax toxin receptor 2, also known as ANTXR2, is a human gene.^[1]

[edit] References

^ Entrez Gene: ANTXR2 anthrax toxin receptor 2.

[edit] Further reading

"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.
Bell SE, Mavila A, Salazar R, et al. (2002). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling.". J. Cell. Sci. 114 (Pt 15): 2755-73. PMID 11683410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Abrami L, Liu S, Cosson P, et al. (2003). "Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process.". J. Cell Biol. 160 (3): 321-8. doi:10.1083/jcb.200211018. PMID 12551953.
Scobie HM, Rainey GJ, Bradley KA, Young JA (2003). "Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor.". Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5170-4. doi:10.1073/pnas.0431098100. PMID 12700348.
Dowling O, Difeo A, Ramirez MC, et al. (2003). "Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis.". Am. J. Hum. Genet. 73 (4): 957-66. PMID 12973667.
Hanks S, Adams S, Douglas J, et al. (2003). "Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis.". Am. J. Hum. Genet. 73 (4): 791-800. PMID 14508707.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Wigelsworth DJ, Krantz BA, Christensen KA, et al. (2004). "Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen.". J. Biol. Chem. 279 (22): 23349-56. doi:10.1074/jbc.M401292200. PMID 15044490.
Lacy DB, Wigelsworth DJ, Scobie HM, et al. (2004). "Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor.". Proc. Natl. Acad. Sci. U.S.A. 101 (17): 6367-72. doi:10.1073/pnas.0401506101. PMID 15079089.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Santelli E, Bankston LA, Leppla SH, Liddington RC (2004). "Crystal structure of a complex between anthrax toxin and its host cell receptor.". Nature 430 (7002): 905-8. doi:10.1038/nature02763. PMID 15243628.
Lacy DB, Wigelsworth DJ, Melnyk RA, et al. (2004). "Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation.". Proc. Natl. Acad. Sci. U.S.A. 101 (36): 13147-51. doi:10.1073/pnas.0405405101. PMID 15326297.
Abrami L, Lindsay M, Parton RG, et al. (2004). "Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway.". J. Cell Biol. 166 (5): 645-51. doi:10.1083/jcb.200312072. PMID 15337774.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lee JY, Tsai YM, Chao SC, Tu YF (2005). "Capillary morphogenesis gene-2 mutation in infantile systemic hyalinosis: ultrastructural study and mutation analysis in a Taiwanese infant.". Clin. Exp. Dermatol. 30 (2): 176-9. doi:10.1111/j.1365-2230.2004.01698.x. PMID 15725249.
Abrami L, Leppla SH, van der Goot FG (2006). "Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis.". J. Cell Biol. 172 (2): 309-20. doi:10.1083/jcb.200507067. PMID 16401723.
Gao M, Schulten K (2007). "Onset of anthrax toxin pore formation.". Biophys. J. 90 (9): 3267-79. doi:10.1529/biophysj.105.079376. PMID 16473908.
Wei W, Lu Q, Chaudry GJ, et al. (2006). "The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin.". Cell 124 (6): 1141-54. doi:10.1016/j.cell.2005.12.045. PMID 16564009.