ANP32C

From Wikipedia, the free encyclopedia


Acidic (leucine-rich) nuclear phosphoprotein 32 family, member C
Identifiers
Symbol(s) ANP32C; PP32R1
External IDs OMIM: 606877 HomoloGene: 49316
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23520 n/a
Ensembl ENSG00000184701 n/a
Uniprot O43423 n/a
Refseq NM_012403 (mRNA)
NP_036535 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 4: 165.34 - 165.34 Mb n/a
Pubmed search [1] n/a

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member C, also known as ANP32C, is a human gene.[1]

Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns.[1]

[edit] References

  1. ^ a b Entrez Gene: ANP32C acidic (leucine-rich) nuclear phosphoprotein 32 family, member C.

[edit] Further reading

  • Matilla A, Radrizzani M (2005). "The Anp32 family of proteins containing leucine-rich repeats.". Cerebellum 4 (1): 7-18. PMID 15895553. 
  • Kochevar GJ, Brody JR, Kadkol SS, et al. (2004). "Identification of a functional mutation in pp32r1 (ANP32C).". Hum. Mutat. 23 (6): 546-51. doi:10.1002/humu.20030. PMID 15146458. 
  • Fan Z, Beresford PJ, Zhang D, et al. (2003). "Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.". Nat. Immunol. 4 (2): 145-53. doi:10.1038/ni885. PMID 12524539. 
  • Kadkol SS, El Naga GA, Brody JR, et al. (2002). "Expression of pp32 gene family members in breast cancer.". Breast Cancer Res. Treat. 68 (1): 65-73. PMID 11678310. 
  • Bai J, Brody JR, Kadkol SS, Pasternack GR (2001). "Tumor suppression and potentiation by manipulation of pp32 expression.". Oncogene 20 (17): 2153-60. doi:10.1038/sj.onc.1204294. PMID 11360199. 
  • Kadkol SS, Brody JR, Pevsner J, et al.. "Correction to "Modulation of oncogenic potential by alternative gene use in human prostate cancer"". Nat. Med. 5 (9): 1087. doi:10.1038/12530. PMID 10471270. 
  • Brody JR, Kadkol SS, Mahmoud MA, et al. (1999). "Identification of sequences required for inhibition of oncogene-mediated transformation by pp32.". J. Biol. Chem. 274 (29): 20053-5. PMID 10400610. 
  • Kadkol SS, Brody JR, Pevsner J, et al. (1999). "Modulation of oncogenic potential by alternative gene use in human prostate cancer.". Nat. Med. 5 (3): 275-9. doi:10.1038/6488. PMID 10086381. 
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