ANLN

From Wikipedia, the free encyclopedia

Anillin, actin binding protein

Identifiers

ANLN; ANILLIN; DKFZp779A055; Scraps; scra

External IDs

MGI: 1920174 HomoloGene: 41281

Gene ontology
Molecular Function:	• actin binding
Cellular Component:	• nucleus • contractile ring
Biological Process:	• cytokinesis • septin ring assembly • cell cycle • mitosis • regulation of exit from mitosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018685 (mRNA)
NP_061155 (protein)

NM_028390 (mRNA)
NP_082666 (protein)

Location

Chr 7: 36.4 - 36.46 Mb

Chr 9: 22.08 - 22.14 Mb

Pubmed search

[1]

[2]

Anillin, actin binding protein, also known as ANLN, is a human gene.^[1]

[edit] References

^ Entrez Gene: ANLN anillin, actin binding protein.

[edit] Further reading

Oegema K, Savoian MS, Mitchison TJ, Field CM (2000). "Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis.". J. Cell Biol. 150 (3): 539–52. PMID 10931866.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kinoshita M, Field CM, Coughlin ML, et al. (2003). "Self- and actin-templated assembly of Mammalian septins.". Dev. Cell 3 (6): 791–802. PMID 12479805.
Straight AF, Cheung A, Limouze J, et al. (2003). "Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor.". Science 299 (5613): 1743–7. doi:10.1126/science.1081412. PMID 12637748.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Straight AF, Field CM, Mitchison TJ (2005). "Anillin binds nonmuscle myosin II and regulates the contractile ring.". Mol. Biol. Cell 16 (1): 193–201. doi:10.1091/mbc.E04-08-0758. PMID 15496454.
Mollinari C, Kleman JP, Saoudi Y, et al. (2005). "Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not.". Mol. Biol. Cell 16 (3): 1043–55. doi:10.1091/mbc.E04-04-0346. PMID 15616196.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Monzo P, Gauthier NC, Keslair F, et al. (2005). "Clues to CD2-associated protein involvement in cytokinesis.". Mol. Biol. Cell 16 (6): 2891–902. doi:10.1091/mbc.E04-09-0773. PMID 15800069.
Zhao WM, Fang G (2005). "Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis.". J. Biol. Chem. 280 (39): 33516–24. doi:10.1074/jbc.M504657200. PMID 16040610.
Zhao WM, Fang G (2005). "MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.". Proc. Natl. Acad. Sci. U.S.A. 102 (37): 13158–63. doi:10.1073/pnas.0504145102. PMID 16129829.
Hall PA, Todd CB, Hyland PL, et al. (2006). "The septin-binding protein anillin is overexpressed in diverse human tumors.". Clin. Cancer Res. 11 (19 Pt 1): 6780–6. doi:10.1158/1078-0432.CCR-05-0997. PMID 16203764.
Suzuki C, Daigo Y, Ishikawa N, et al. (2006). "ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway.". Cancer Res. 65 (24): 11314–25. doi:10.1158/0008-5472.CAN-05-1507. PMID 16357138.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.