ANKFY1

From Wikipedia, the free encyclopedia

Ankyrin repeat and FYVE domain containing 1

Identifiers

ANKFY1; ANKHZN; DKFZp686M19106; KIAA1255; ZFYVE14

External IDs

OMIM: 607927 MGI: 1337008 HomoloGene: 9491

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • metal ion binding
Cellular Component:	• endosome membrane • membrane
Biological Process:	• endocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016376 (mRNA)
NP_057460 (protein)

NM_009671 (mRNA)
NP_033801 (protein)

Location

Chr 17: 4.01 - 4.11 Mb

Chr 11: 72.51 - 72.59 Mb

Pubmed search

[1]

[2]

Ankyrin repeat and FYVE domain containing 1, also known as ANKFY1, is a human gene.^[1]

This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle or protein transport. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: ANKFY1 ankyrin repeat and FYVE domain containing 1.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Ito K, Ishii N, Miyashita A, et al. (1999). "Molecular cloning of a novel 130-kDa cytoplasmic protein, Ankhzn, containing Ankyrin repeats hooked to a zinc finger motif.". Biochem. Biophys. Res. Commun. 257 (1): 206–13. doi:10.1006/bbrc.1999.0430. PMID 10092534.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. PMID 10574462.
Kuriyama H, Asakawa S, Minoshima S, et al. (2000). "Characterization and chromosomal mapping of a novel human gene, ANKHZN.". Gene 253 (2): 151–60. PMID 10940552.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Schnatwinkel C, Christoforidis S, Lindsay MR, et al. (2006). "The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.". PLoS Biol. 2 (9): E261. doi:10.1371/journal.pbio.0020261. PMID 15328530.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.