Anhydrotetracycline monooxygenase

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In enzymology, an anhydrotetracycline monooxygenase (EC 1.14.13.38) is an enzyme that catalyzes the chemical reaction

anhydrotetracycline + NADPH + H⁺ + O₂ 12-dehydrotetracycline + NADP⁺ + H₂O

The 4 substrates of this enzyme are anhydrotetracycline, NADPH, H⁺, and O₂, whereas its 3 products are 12-dehydrotetracycline, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating). Other names in common use include ATC oxygenase, and anhydrotetracycline oxygenase. This enzyme participates in tetracycline biosynthesis and biosynthesis of type ii polyketide products.

[edit] References

• IUBMB entry for 1.14.13.38
• BRENDA references for 1.14.13.38 (Recommended.)
• PubMed references for 1.14.13.38
• PubMed Central references for 1.14.13.38
• Google Scholar references for 1.14.13.38
• Behal V (1987). "The tetracycline fermentation and its regulation". CRC Crit. Rev. Biotechnol. 5: 295–318. 

[edit] External links

The CAS registry number for this enzyme class is 70766-62-0.

• IUBMB entry for 1.14.13.38

• KEGG entry for 1.14.13.38

• BRENDA entry for 1.14.13.38

• NiceZyme view of 1.14.13.38

• EC2PDB: PDB structures for 1.14.13.38

• PRIAM entry for 1.14.13.38

• PUMA2 entry for 1.14.13.38

• IntEnz: Integrated Enzyme entry for 1.14.13.38

• MetaCyc entry for 1.14.13.38

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047670: anhydrotetracycline monooxygenase

• AMIGO entry for GO code 0047670: anhydrotetracycline monooxygenase