Talk:Angelman syndrome
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[edit] Imprinting
There's a contradiction between the statement about imprinting (an AS father can have a Prader-Willi daughter, which I agree is possible in theory according to what's known about the genetics of each syndrome) and the statement that no one with AS has ever been known to have a child. BLAH!
Is the statement about the person with AS fathering a daughter with PW theoretical only, or has it ever been shown to occur? -Ikkyu2 03:52, 31 August 2005 (UTC) unsigned)
Imprinting (which is discussed in the wikipedia article) explains how the same grm. An individual gets one copy of 15 from paternal and maternal sources, but either copy that he/she gives up to offspring, must be reset to paternal, if the person in question is a guy; or maternal if she is a woman. Every copy of chromosome 15 in a sperm should be paternal imprinted, despite the fact that 50% of them WERE maternally imprinted before spermatogensis. So in theory it might be possible for an AS or a PW patient to have even a normal son or daughter, or there might be an increased risk of either AS/PW. However, many of the deficits in both are severe and fertility might be affected, and life span might be shorted to the point where offspring are unlikely. DocGratis 01:03, 3 June 2007 (UTC)
[edit] Links
Added some links to the Angelman page, however, some editors are saying that they think the links shouldn't be there. Some of the links added are to various countries websites containing further information on AS. In my opinion these links should be there, because they support the document in providing more information, as do the forum links. Aussieland 20:25, 13 December 2006 (UTC)
Pub med link to article
[edit] I think I've got this
I have all symptoms expept below adverage head size and epilepsy, my head is larger than normal. What should I do?—Preceding unsigned comment added by 124.197.54.130 (talk • contribs)
-no, you don't. the article is pretty accurate when it suggests that a best case scenario with Angelman Syndrome would be a vocabulary of about 50 words. none of those words are likely to be 'epilepsy'. 70.139.127.53 00:37, 15 August 2007 (UTC)
[edit] Angelman != Aspergers
I removed "Although often considered part of the autistic spectrum" from the article. Angelman syndrome is not at all considered part of the autistic spectrum. I've studied both and met and worked with people with Angelman Syndrome and people from all over the autistic spectrum, and there's no mistaking one for the other. 70.139.127.53 00:37, 15 August 2007 (UTC)
