ANGPTL4

From Wikipedia, the free encyclopedia

Angiopoietin-like 4

Identifiers

ANGPTL4; ARP4; ANGPTL2; FIAF; HFARP; NL2; PGAR; pp1158

External IDs

OMIM: 605910 MGI: 1888999 HomoloGene: 10755

Gene ontology
Molecular Function:	• enzyme inhibitor activity • receptor binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• angiogenesis • response to hypoxia • signal transduction • multicellular organismal development • cellular response to starvation • cell differentiation • negative regulation of apoptosis • positive regulation of angiogenesis • positive regulation of lipid metabolic process • negative regulation of lipoprotein lipase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001039667 (mRNA)
NP_001034756 (protein)

NM_020581 (mRNA)
NP_065606 (protein)

Location

Chr 19: 8.34 - 8.35 Mb

Chr 17: 33.38 - 33.39 Mb

Pubmed search

[1]

[2]

Angiopoietin-like 4, also known as ANGPTL4, is a human gene.^[1]

This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.^[1]

ANGPTL4 inhibits lipoprotein lipase, LPL, by breaking the dimer molecule. ANGPTL3 and ANGPTL4 have been unambiguously established as potent inhibitors of blood plasma Triglyceride (TG) clearance, causing elevation of plasma TG levels.

[edit] References

^ ^a ^b Entrez Gene: ANGPTL4 angiopoietin-like 4.

S Kersten - Regulation of lipid metabolism via angiopoietin-like proteins - Biochem Soc Trans, 2005 - bst.portlandpress.com

[edit] Further reading

Li C (2007). "Genetics and regulation of angiopoietin-like proteins 3 and 4.". Curr. Opin. Lipidol. 17 (2): 152-6. doi:10.1097/01.mol.0000217896.67444.05. PMID 16531751.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Kim I, Kim HG, Kim H, et al. (2000). "Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis.". Biochem. J. 346 Pt 3: 603-10. PMID 10698685.
Yoon JC, Chickering TW, Rosen ED, et al. (2000). "Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.". Mol. Cell. Biol. 20 (14): 5343-9. PMID 10866690.
Gbaguidi FG, Chinetti G, Milosavljevic D, et al. (2002). "Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages.". FEBS Lett. 512 (1-3): 85-90. PMID 11852057.
Mujumdar VS, Tummalapalli CM, Aru GM, Tyagi SC (2002). "Mechanism of constrictive vascular remodeling by homocysteine: role of PPAR.". Am. J. Physiol., Cell Physiol. 282 (5): C1009-15. doi:10.1152/ajpcell.00353.2001. PMID 11940516.
Zhu H, Li J, Qin W, et al. (2002). "[Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis]". Zhonghua Yi Xue Za Zhi 82 (2): 94-9. PMID 11953136.
Zhu H, Li J, Wan D, et al. (2002). "[Expression and function of hepatocellular carcinoma-related gene pp1158]". Zhonghua Zhong Liu Za Zhi 24 (2): 123-5. PMID 12015030.
Kaneda A, Kaminishi M, Yanagihara K, et al. (2002). "Identification of silencing of nine genes in human gastric cancers.". Cancer Res. 62 (22): 6645-50. PMID 12438262.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yoshimura R, Matsuyama M, Segawa Y, et al. (2003). "Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists.". Int. J. Cancer 104 (5): 597-602. doi:10.1002/ijc.10980. PMID 12594814.
Le Jan S, Amy C, Cazes A, et al. (2003). "Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma.". Am. J. Pathol. 162 (5): 1521-8. PMID 12707035.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Ito Y, Oike Y, Yasunaga K, et al. (2003). "Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4.". Cancer Res. 63 (20): 6651-7. PMID 14583458.
Mandard S, Zandbergen F, Tan NS, et al. (2004). "The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment.". J. Biol. Chem. 279 (33): 34411-20. doi:10.1074/jbc.M403058200. PMID 15190076.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Fink T, Abildtrup L, Fogd K, et al. (2005). "Induction of adipocyte-like phenotype in human mesenchymal stem cells by hypoxia.". Stem Cells 22 (7): 1346-55. doi:10.1634/stemcells.2004-0038. PMID 15579652.
Xu A, Lam MC, Chan KW, et al. (2005). "Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice.". Proc. Natl. Acad. Sci. U.S.A. 102 (17): 6086-91. doi:10.1073/pnas.0408452102. PMID 15837923.
Hermann LM, Pinkerton M, Jennings K, et al. (2005). "Angiopoietin-like-4 is a potential angiogenic mediator in arthritis.". Clin. Immunol. 115 (1): 93-101. doi:10.1016/j.clim.2004.12.002. PMID 15870027.