ANGPT4

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Angiopoietin 4
Identifiers
Symbol(s) ANGPT4; AGP4; ANG-3; ANG4; MGC138181; MGC138183
External IDs OMIM: 603705 MGI: 1336887 HomoloGene: 36302
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51378 11602
Ensembl ENSG00000101280 ENSMUSG00000027460
Uniprot Q9Y264 Q3U486
Refseq NM_015985 (mRNA)
NP_057069 (protein)		 NM_009641 (mRNA)
NP_033771 (protein)
Location Chr 20: 0.8 - 0.84 Mb Chr 2: 151.6 - 151.64 Mb
Pubmed search [1] [2]

Angiopoietin 4, also known as ANGPT4, is a human gene.[1]

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin.[1]

[edit] References

  1. ^ a b Entrez Gene: ANGPT4 angiopoietin 4.

[edit] Further reading

  • Valenzuela DM, Griffiths JA, Rojas J, et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. PMID 10051567. 
  • Nishimura M, Miki T, Yashima R, et al. (1999). "Angiopoietin-3, a novel member of the angiopoietin family.". FEBS Lett. 448 (2-3): 254–6. PMID 10218486. 
  • Grosios K, Leek JP, Markham AF, et al. (1999). "Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping.". Cytogenet. Cell Genet. 84 (1-2): 118–20. PMID 10343124. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Ward EG, Grosios K, Markham AF, Jones PF (2002). "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2.". Cytogenet. Cell Genet. 94 (3-4): 147–54. PMID 11856872. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart.". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729. 
  • Yamakawa M, Liu LX, Belanger AJ, et al. (2004). "Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis.". Am. J. Physiol. Renal Physiol. 287 (4): F649–57. doi:10.1152/ajprenal.00028.2004. PMID 15198927. 
  • Lee HJ, Cho CH, Hwang SJ, et al. (2005). "Biological characterization of angiopoietin-3 and angiopoietin-4.". FASEB J. 18 (11): 1200–8. doi:10.1096/fj.03-1466com. PMID 15284220. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Oliner J, Min H, Leal J, et al. (2004). "Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.". Cancer Cell 6 (5): 507–16. doi:10.1016/j.ccr.2004.09.030. PMID 15542434. 
  • Olsen MW, Ley CD, Junker N, et al. (2006). "Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure.". Neoplasia 8 (5): 364–72. doi:10.1593/neo.06127. PMID 16790085. 
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