ANGPT2

From Wikipedia, the free encyclopedia

Angiopoietin 2

PDB rendering based on 1z3s.

Available structures: 1z3s, 1z3u, 2gy7

Identifiers

Symbol(s)

ANGPT2; AGPT2; ANG2

External IDs

OMIM: 601922 MGI: 1202890 HomoloGene: 22401

Gene ontology
Molecular Function:	• receptor binding
Cellular Component:	• extracellular space
Biological Process:	• angiogenesis • signal transduction • multicellular organismal development • negative regulation of angiogenesis • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001147 (mRNA)
NP_001138 (protein)

NM_007426 (mRNA)
NP_031452 (protein)

Location

Chr 8: 6.34 - 6.41 Mb

Chr 8: 18.69 - 18.74 Mb

Pubmed search

[1]

[2]

Angiopoietin 2, also known as ANGPT2, is a human gene.

Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1^[1]

[edit] See also

Angiopoietin

[edit] References

^ Entrez Gene: ANGPT2 angiopoietin 2.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Maisonpierre PC, Suri C, Jones PF, et al. (1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.". Science 277 (5322): 55–60. PMID 9204896.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Cheung AH, Stewart RJ, Marsden PA (1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23.". Genomics 48 (3): 389–91. doi:10.1006/geno.1997.5207. PMID 9545648.
Sato A, Iwama A, Takakura N, et al. (1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells.". Int. Immunol. 10 (8): 1217–27. PMID 9723709.
Tanaka S, Mori M, Sakamoto Y, et al. (1999). "Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma.". J. Clin. Invest. 103 (3): 341–5. PMID 9927494.
Valenzuela DM, Griffiths JA, Rojas J, et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. PMID 10051567.
Grosios K, Leek JP, Markham AF, et al. (1999). "Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping.". Cytogenet. Cell Genet. 84 (1-2): 118–20. PMID 10343124.
Procopio WN, Pelavin PI, Lee WM, Yeilding NM (1999). "Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity.". J. Biol. Chem. 274 (42): 30196–201. PMID 10514510.
Kim I, Kim JH, Ryu YS, et al. (2000). "Characterization and expression of a novel alternatively spliced human angiopoietin-2.". J. Biol. Chem. 275 (24): 18550–6. doi:10.1074/jbc.M910084199. PMID 10766762.
Mezquita J, Mezquita P, Montserrat P, et al. (2000). "Genomic structure and alternative splicing of chicken angiopoietin-2.". Biochem. Biophys. Res. Commun. 275 (2): 643–51. doi:10.1006/bbrc.2000.3345. PMID 10964717.
Xu Y, Yu Q (2001). "Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region.". J. Biol. Chem. 276 (37): 34990–8. doi:10.1074/jbc.M103661200. PMID 11447223.
Acker T, Beck H, Plate KH (2002). "Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization.". Mech. Dev. 108 (1-2): 45–57. PMID 11578860.
Ward EG, Grosios K, Markham AF, Jones PF (2002). "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2.". Cytogenet. Cell Genet. 94 (3-4): 147–54. PMID 11856872.
Huang YQ, Li JJ, Hu L, et al. (2002). "Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells.". Blood 99 (5): 1646–50. PMID 11861279.
Hata K, Udagawa J, Fujiwaki R, et al. (2002). "Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer.". Oncology 62 (4): 340–8. PMID 12138242.
Lin S, Shyu KG, Lee CC, et al. (2002). "Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells.". Biochem. Biophys. Res. Commun. 296 (3): 710–5. PMID 12176040.
Geva E, Ginzinger DG, Zaloudek CJ, et al. (2002). "Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2.". J. Clin. Endocrinol. Metab. 87 (9): 4213–24. PMID 12213874.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Paradis V, Bièche I, Dargère D, et al. (2003). "A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia.". Gastroenterology 124 (3): 651–9. doi:10.1053/gast.2003.50104. PMID 12612904.