Andropause

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Andropause (sometimes called male menopause[1]) is a somewhat misleading term which is sometimes used to describe a reduction of the production of certain hormones such as testosterone and dehydroepiandrosterone, and the consequences of that reduction,[2] which is associated with a decrease in Leydig cells.[3][4] The term andropause is misleading (as is the term "male menopause"), because it suggests an equivalence with menopause, a complete and permanent shutting down of the reproductive system, which occurs only in women.

The term "andropause" does appear frequently in peer-reviewed journal articles, both with and without scare quotes, however there is an on-going controversy about whether or not andropause is a "state" (the term used by MeSH), or a disorder. A decline in testosterone level with age is well documented,[5] but there is disagreement over how a "normal" or "healthy" state should be defined. Researchers who oppose the use of the term "andropause" usually don't object to the more limited terms "SLOH" or "ADAM", described in more detail below.

Contents

[edit] Andropause as a "state"

The impact of low levels of testosterone has been previously reported. In 1944, Heller and Myers[6] identified symptoms of what they labeled the "male climacteric" including loss of libido and potency, nervousness, depression, impaired memory, the inability to concentrate, fatigue, insomnia, hot flushes, and sweating. Heller and Myers found that their subjects had lower than normal levels of testosterone, and that symptoms improved dramatically when patients were given replacement doses of testosterone.

Andropause has been observed in association with Alzheimer's disease.[7]

In one study, 98.0% of primary care physicians believed that andropause and osteoporosis risk were related.[8]

The term "symptomatic late onset hypogonadism" (or "SLOH") is sometimes considered to refer to the same condition as the word "andropause".[9] [10]

Some researchers prefer the term "androgen deficiency of the aging male" ("ADAM"), to more accurately reflect the fact that the loss of testosterone production is gradual and asymptotic[11] (in contrast to the more abrupt change associated with menopause[citation needed].) The "D" is sometimes given as "decline" instead of "deficiency".[9] In some contexts, the term "partial androgen deficiency in aging males" ("PADAM") is used instead.[12]

[edit] Andropause as a "disorder"

[edit] Proponents

Its proponents claim that it is a biological change experienced by men during their mid-life, and is often compared to female menopause. Menopause however is a complete cessation of reproductive ability caused by the shutting down of the female reproductive system in its entirety. Andropause on the other hand is a diminishment of the key male hormone testosterone. This drop in testosterone levels is considered to lead in some cases to loss of energy and concentration, depression, and mood swings. Unlike menopause, andropause does not cause a man's reproductive system to stop working altogether in mid-life, but many will experience bouts of impotence.

Some of the current popular interest in andropause has been fueled by the book Male Menopause, written by Jed Diamond.[13] According to Diamond, andropause is a change of life in middle-aged men, which has hormonal, physical, psychological, interpersonal, social, sexual, and spiritual aspects. Diamond claims that this change occurs in all men, generally between the ages of 40 and 55, though it can occur as early as 35 or as late as 65. Some argue the term "male menopause" is a misnomer, as unlike women, men's reproductive systems do not cease to work completely in mid-life; some men continue to father children late into their lives (at age 90 or older[14]). But Diamond claims that, in terms of other life impacts, women’s and men’s experience are somewhat similar phenomena.[15][16][17]

The concept of andropause is perhaps more widely accepted in Australia and some parts of Europe than it is in the United States.[18]

[edit] Opponents

In the U.S., many clinicians believe that, since men can continue to reproduce into old age, and do not universally show the same dramatic drops in hormone levels characteristic of menopause in women, andropause is nonexistent. Others feel that andropause is real, synonymous with hypogonadism or low testosterone levels.[17] Opposition is not limited to the US.[19]

The role of hormones, generally speaking, is an unsettled area of science. Some argue that many of the cited symptoms are not specific enough to warrant describing a new condition as the cause. People who are overweight may be misguided into treating a 'new illness' rather than addressing the lifestyle that lead to being overweight. Similarly, energy levels vary naturally, and for those who are inactive, they are lower overall.

While it is true that active and otherwise healthy men might develop andropause-like symptoms, how common and widespread the phenomenon is, and whether genetics, lifestyle, environment, or a combination of factors are responsible, continues to be studied.

Unlike menopause, the term "andropause" is not currently recognized by the World Health Organization and its ICD-10 medical classification.

[edit] Diagnosis

Although there is disagreement over whether or not andropause is a condition to be "diagnosed" and "treated", those who support that position have made several proposals to address andropause and mitigate some of its effects.

  • Morley emphasizes the importance of response to treatment, as well as testosterone level and identifiable symptoms.[20]
  • Mintz, Dotson, & Mukai include an emphasis on hormones other than testosterone. They also focus upon diet, and exercise. [21]
  • Diamond believes that depression is one of the most common problems of men going through andropause, and feels it is greatly under-diagnosed in men, with serious consequences.[22]

[edit] Treatment

Several intervention strategies have been found to be effective.[13] [16] [22] [18] These include:

  • Finding and engaging one’s “calling” in the second half of life[citation needed]

Selective androgen receptor modulators have also been proposed.[24]

[edit] References

  1. ^ Male Menopause. Retrieved on 2007-12-17.
  2. ^ MeSH Andropause
  3. ^ a_36/14179710 at Dorland's Medical Dictionary
  4. ^ Mahmoud A, Comhaire FH (2006). "Mechanisms of disease: late-onset hypogonadism". Nat Clin Pract Urol 3 (8): 430–8. doi:10.1038/ncpuro0560. PMID 16902519. 
  5. ^ Mooradian AD, Korenman SG (2006). "Management of the cardinal features of andropause". Am J Ther 13 (2): 145–60. doi:10.1097/01.mjt.0000132252.80403.c9. PMID 16645432. 
  6. ^ Heller, C.G., Myers, G.B., “The Male climacteric: Its symptomatology, diagnosis and treatment.” JAMA 1944; 126:472-77.
  7. ^ Fuller SJ, Tan RS, Martins RN (2007). "Androgens in the etiology of Alzheimer's disease in aging men and possible therapeutic interventions". J. Alzheimers Dis. 12 (2): 129–42. PMID 17917157. 
  8. ^ Pommerville PJ, Zakus P (2006). "Andropause: knowledge and awareness among primary care physicians in Victoria, BC, Canada". Aging Male 9 (4): 215–20. doi:10.1080/13685530601040661. PMID 17178557. 
  9. ^ a b Columbia Presbyterian - Department of Urology. Retrieved on 2007-12-17.
  10. ^ There's help for "grumpy old men", but they're reluctant to admit to problem, says Queen's urologist. Retrieved on 2007-12-17.
  11. ^ Morales A (2004). "Andropause (or symptomatic late-onset hypogonadism): facts, fiction and controversies". Aging Male 7 (4): 297–303. doi:10.1080/13685530400016664. PMID 15799125. 
  12. ^ Tancredi A, Reginster JY, Luyckx F, Legros JJ (2005). "No major month to month variation in free testosterone levels in aging males. Minor impact on the biological diagnosis of 'andropause'". Psychoneuroendocrinology 30 (7): 638–46. doi:10.1016/j.psyneuen.2005.02.002. PMID 15854780. 
  13. ^ a b Diamond, Jed (1998). Male Menopause. Naperville, Ill: Sourcebooks. ISBN 1-57071-397-9. 
  14. ^ "Father, 90, shows off new baby" - timesonline.co.uk, retrieved 9/08/07
  15. ^ Cetel, Nancy (2002). Double Menopause: What to Do When Both You and Your Mate Have Hormonal Changes Together. New York: Wiley. ISBN 0-471-40262-1. 
  16. ^ a b Diamond, Jed (2000). Surviving Male Menopause. A Guide for Women and Men. Naperville, Ill: Sourcebooks. ISBN 1-57071-433-9. 
  17. ^ a b Tan, Robert S. (2001). The andropause mystery: unraveling truths about the male menopause. Houston, Tex: AMRED Pub. ISBN 0-9707061-0-3. 
  18. ^ a b Carruthers, Malcolm (2004). Androgen Deficiency in the Aging Male. London: Taylor & Francis Group. ISBN 1-84214-032-9. 
  19. ^ Juul A, Skakkebaek NE (2002). "[Testosterone treatment of elderly men. The so called andropause doesn't exist]" (in Danish). Ugeskr. Laeg. 164 (42): 4941–2. PMID 12416079. 
  20. ^ Morley JE (2007). "The diagnosis of late life hypogonadism". Aging Male 10 (4): 217–20. doi:10.1080/13685530701695463. PMID 18033631. 
  21. ^ Mintz, A.P., Dotson, A. & Mukai, J. Hormone modulation, low glycemic nutrition, and exercise instruction: Effects on disease risk and quality of life. Journal of Anti-Aging Medicine, 4, 357-371, 2001. link
  22. ^ a b Diamond, Jed (2004). The Irritable Male Syndrome : Managing the Four Key Causes of Depression and Aggression. Emmaus, Pa: Rodale Books. ISBN 1-57954-798-2. 
  23. ^ a b Tan, Robert S. (205). Aging Men's Health: A Case-Based Approach. New York: Thieme Medical Publishers. ISBN 1-58890-296-X. 
  24. ^ Tan RS, Pu SJ, Culberson JW (2003). "Role of androgens in mild cognitive impairment and possible interventions during andropause". Med. Hypotheses 60 (3): 448–52. doi:10.1016/S0306-9877(02)00447-4. PMID 12581627. 

[edit] See also

[edit] External links

v • d • e
Human physiology and endocrinology of reproduction
Anatomy and physiology
Menstrual/Estrous cycle
Gametogenesis
Sexuality
Lifespan
Eggs
Reproductive endocrinology