AMY2B

From Wikipedia, the free encyclopedia

Amylase, alpha 2B (pancreatic)

PDB rendering based on 1b2y.

Available structures: 1b2y, 1bsi, 1c8q, 1cpu, 1hny, 1jxj, 1jxk, 1kb3, 1kbb, 1kbk, 1kgu, 1kgw, 1kgx, 1mfu, 1mfv, 1nm9, 1q4n, 1smd, 1u2y, 1u30, 1u33, 1xcw, 1xcx, 1xd0, 1xd1, 1xgz, 1xh0, 1xh1, 1xh2, 1xv8, 1z32, 2cpu, 3cpu

Identifiers

Symbol(s)

AMY2B; AMY2

External IDs

OMIM: 104660 HomoloGene: 88874

Gene ontology
Molecular Function:	• alpha-amylase activity • calcium ion binding • hydrolase activity, acting on glycosyl bonds • chloride ion binding
Cellular Component:	• extracellular space
Biological Process:	• carbohydrate metabolic process • digestion • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_020978 (mRNA)
NP_066188 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 1: 103.9 - 103.92 Mb

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Pubmed search

[1]

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Amylase, alpha 2B (pancreatic), also known as AMY2B, is a human gene.^[1]

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.^[1]

[edit] References

^ ^a ^b Entrez Gene: AMY2B amylase, alpha 2B (pancreatic).

[edit] Further reading

Kaczmarek MJ, Rosenmund H (1977). "The action of human pancreatic and salivary isoamylases on starch and glycogen.". Clin. Chim. Acta 79 (1): 69–73. PMID 890964.
Groot PC, Mager WH, Henriquez NV, et al. (1991). "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers.". Genomics 8 (1): 97–105. PMID 2081604.
Yokouchi H, Horii A, Emi M, et al. (1990). "Cloning and characterization of a third type of human alpha-amylase gene, AMY2B.". Gene 90 (2): 281–6. PMID 2401405.
Gumucio DL, Wiebauer K, Caldwell RM, et al. (1988). "Concerted evolution of human amylase genes.". Mol. Cell. Biol. 8 (3): 1197–205. PMID 2452973.
Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH (1988). "Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene.". Nucleic Acids Res. 16 (17): 8261–76. PMID 2458567.
Tomita N, Horii A, Doi S, et al. (1989). "A novel type of human alpha-amylase produced in lung carcinoid tumor.". Gene 76 (1): 11–8. PMID 2701942.
Groot PC, Bleeker MJ, Pronk JC, et al. (1989). "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes.". Genomics 5 (1): 29–42. PMID 2788608.
Groot PC, Bleeker MJ, Pronk JC, et al. (1988). "Human pancreatic amylase is encoded by two different genes.". Nucleic Acids Res. 16 (10): 4724. PMID 3260028.
Tricoli JV, Shows TB (1984). "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1.". Somat. Cell Mol. Genet. 10 (2): 205–10. PMID 6608795.
Omichi K, Hase S (1994). "Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene.". Biochim. Biophys. Acta 1203 (2): 224–9. PMID 8268204.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. PMID 11347906.
Aughsteen AA (2001). "A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas.". Saudi medical journal 22 (5): 410–5. PMID 11376382.
Koyama I, Komine S, Iino N, et al. (2001). "alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues.". Clin. Chim. Acta 309 (1): 73–83. PMID 11408008.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Iafrate AJ, Feuk L, Rivera MN, et al. (2004). "Detection of large-scale variation in the human genome.". Nat. Genet. 36 (9): 949–51. doi:10.1038/ng1416. PMID 15286789.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.