Amsterdam criteria

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The Amsterdam criteria identify families likely to have Hereditary nonpolyposis colorectal cancer (HNPCC).

At least 3 relatives with an HNPCC-associated cancer: colorectal cancer, or cancer of the endometrium, small intestine, ureter or renal pelvis.

• One patient should be a first degree relative of the other two

• At least two successive generations should be affected

• At least one tumour should be diagnosed <50 years of age

• Familial adenomatous polyposis should be excluded in the colorectal cancer case (if any)

• Tumours should be verified by histopathologic examination

[edit] References

• http://www.jeffersonhospital.org/cancer/article3099.html

• http://www.medscape.com/viewarticle/466572_4