AMP nucleosidase
From Wikipedia, the free encyclopedia
In enzymology, an AMP nucleosidase (EC 3.2.2.4) is an enzyme that catalyzes the chemical reaction
- AMP + H2O D-ribose 5-phosphate + adenine
Thus, the two substrates of this enzyme are AMP and H2O, whereas its two products are D-ribose 5-phosphate and adenine.
This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is AMP phosphoribohydrolase. Other names in common use include adenylate nucleosidase, and adenosine monophosphate nucleosidase. This enzyme participates in purine metabolism.
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[edit] Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1T8R, 1T8S, 1T8W, 1T8Y, and 2GUW.
[edit] References
- IUBMB entry for 3.2.2.4
- BRENDA references for 3.2.2.4 (Recommended.)
- PubMed references for 3.2.2.4
- PubMed Central references for 3.2.2.4
- Google Scholar references for 3.2.2.4
- Hurwitz J, Heppel LA and Horecker BL (1957). "The enzymatic cleavage of adenylic acid to adenine and ribose 5-phosphate". J. Biol. Chem. 226: 525–540.
[edit] External links
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- The CAS registry number for this enzyme class is 9025-45-0.