AMOTL1

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Angiomotin like 1
Identifiers
Symbol(s) AMOTL1; JEAP
External IDs MGI: 1922973 HomoloGene: 43977
Orthologs
Human Mouse
Entrez 154810 75723
Ensembl ENSG00000166025 ENSMUSG00000013076
Uniprot Q8IY63 Q9D4H4
Refseq NM_130847 (mRNA)
NP_570899 (protein)		 XM_919481 (mRNA)
XP_924574 (protein)
Location Chr 11: 94.14 - 94.25 Mb Chr 9: 14.3 - 14.39 Mb
Pubmed search [1] [2]

Angiomotin like 1, also known as AMOTL1, is a human gene.[1]

The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.[1]

[edit] References

  1. ^ a b Entrez Gene: AMOTL1 angiomotin like 1.

[edit] Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166. 
  • Nishimura M, Kakizaki M, Ono Y, et al. (2002). "JEAP, a novel component of tight junctions in exocrine cells.". J. Biol. Chem. 277 (7): 5583-7. doi:10.1074/jbc.M110154200. PMID 11733531. 
  • Bratt A, Wilson WJ, Troyanovsky B, et al. (2003). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains.". Gene 298 (1): 69-77. PMID 12406577. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Patrie KM (2005). "Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1.". Biochim. Biophys. Acta 1745 (1): 131-44. doi:10.1016/j.bbamcr.2005.05.011. PMID 16019084. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
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