Aminophylline

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Aminophylline
Systematic (IUPAC) name
1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine
Identifiers
CAS number 317-34-0
ATC code R03DA05
PubChem 9433
DrugBank APRD00329
Chemical data
Formula C16H24N10O4 
Mol. mass 420.427 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 60%
Metabolism  ?
Half life 7-9 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status

P(UK)
Routes oral, i.v.

Aminophylline is a bronchodilator drug combination that contains theophylline and ethylenediamine in 2:1 ratio.

Contents

[edit] Properties

It is more soluble in water than theophylline. White or slightly yellowish granules or powder, having a slight ammoniacal odor and a bitter taste. Upon exposure to air, it gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Its solutions are alkaline. One g dissolves in 25 mL of water to give a clear solution; 1 g dissolved in 5 mL of water crystallizes upon standing, but redissolves when a small amount of ethylenediamine is added. Insoluble in alcohol and in ether.

[edit] Mechanism of action

Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma.

Causes bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis and induces release of epinephrine from adrenal medulla cells

[edit] Brand names

  • Phyllocontin
  • Truphylline

[edit] External links

v • d • e
Drugs for obstructive airway diseases: asthma/COPD (R03)
Adrenergics, inhalants
Glucocorticoids
Anticholinergics
Mast cell stabilizers
Xanthines
Aminophylline • Theobromine • Theophylline
Leukotriene antagonists
Lipoxygenase inhibitor
Combination products