Aminolevulinate transaminase

From Wikipedia, the free encyclopedia

In enzymology, an aminolevulinate transaminase (EC 2.6.1.43) is an enzyme that catalyzes the chemical reaction

5-aminolevulinate + pyruvate 4,5-dioxopentanoate + L-alanine

Thus, the two substrates of this enzyme are 5-aminolevulinate and pyruvate, whereas its two products are 4,5-dioxopentanoate and L-alanine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 5-aminolevulinate:pyruvate aminotransferase. Other names in common use include aminolevulinate aminotransferase, gamma,delta-dioxovalerate, aminotransferase, gamma,delta-dioxovaleric acid transaminase, 4,5-dioxovalerate aminotransferase, 4,5-dioxovaleric acid transaminase, 4,5-dioxovaleric transaminase, 5-aminolevulinic acid transaminase, alanine-gamma,delta-dioxovalerate aminotransferase, alanine-dioxovalerate aminotransferase, alanine:4,5-dioxovalerate aminotransferase, aminolevulinic acid transaminase, dioxovalerate transaminase, L-alanine-4,5-dioxovalerate aminotransferase, L-alanine:4,5-dioxovaleric acid transaminase, L-alanine:dioxovalerate transaminase, DOVA transaminase, and 4,5-dioxovaleric acid aminotransferase. This enzyme participates in porphyrin and chlorophyll metabolism. It employs one cofactor, pyridoxal phosphate.

[edit] References

• IUBMB entry for 2.6.1.43
• BRENDA references for 2.6.1.43 (Recommended.)
• PubMed references for 2.6.1.43
• PubMed Central references for 2.6.1.43
• Google Scholar references for 2.6.1.43
• Gibson KD, Matthew M and Neuberger A (1961). "Biosynthesis of porphyrins and chlorophylls". Nature 192: 204–208. doi:10.1038/192204a0. 
• NEUBERGER A, TURNER JM (1963). "gamma,delta-Dioxovalerate aminotransferase activity in Rhodopseudomonas spheroides". Biochim. Biophys. Acta. 67: 342–5. doi:10.1016/0006-3002(63)91839-0. PMID 13938132. 

[edit] External links

The CAS registry number for this enzyme class is 9012-46-8.

• IUBMB entry for 2.6.1.43

• KEGG entry for 2.6.1.43

• BRENDA entry for 2.6.1.43

• NiceZyme view of 2.6.1.43

• EC2PDB: PDB structures for 2.6.1.43

• PRIAM entry for 2.6.1.43

• PUMA2 entry for 2.6.1.43

• IntEnz: Integrated Enzyme entry for 2.6.1.43

• MetaCyc entry for 2.6.1.43

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047665: aminolevulinate transaminase

• AMIGO entry for GO code 0047665: aminolevulinate transaminase