Aminoglutethimide

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Aminoglutethimide
Systematic (IUPAC) name
3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione
Identifiers
CAS number	125-84-8
ATC code	L02BG01
PubChem	2145
DrugBank	APRD00592
Chemical data
Formula	C13H16N2O2
Mol. mass	232.278 g/mol
Pharmacokinetic data
Bioavailability	>95%
Metabolism	Hepatic
Half life	12.5 ± 1.6 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	D: (USA) D:(AUS)
Legal status
Routes	Oral

Aminoglutethimide blocks the conversion of cholesterol to pregnenolone by inhibiting the enzyme desmolase, thus inhibits synthesis of all hormonally active steroids. It can be used in conjunction with other drugs for treatment of steroid-producing adrenocortical cancer.

Its major side effects are liver toxicity, inhibition of cortisol in the human body, and it may also cause hypothyroidism. Since cortisol helps break down muscle, aminoglutethimide is used by bodybuilders in a steroid cycle.

It is still used to suppress corticosteroid production in Cushing's Syndrome.

It is marketed under the tradename Cytadren.

[edit] Clinical uses

Aminoglutethimide is indicated for the suppression of adrenal function in selected patients with Cushing's syndrome.

[edit] External links

• Cytadren prescribing information (from the FDA website)
• Medline Plus

[edit] See also

• Glutethimide

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