Aminodeoxychorismate synthase

From Wikipedia, the free encyclopedia

In enzymology, an aminodeoxychorismate synthase (EC 6.3.5.8) is an enzyme that catalyzes the chemical reaction

chorismate + L-glutamine 4-amino-4-deoxychorismate + L-glutamate

Thus, the two substrates of this enzyme are chorismate and L-glutamine, whereas its two products are 4-amino-4-deoxychorismate and L-glutamate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is chorismate:L-glutamine amido-ligase. Other names in common use include ADC synthase, 4-amino-4-deoxychorismate synthase, and PabB. This enzyme participates in folate biosynthesis.

[edit] References

• IUBMB entry for 6.3.5.8
• BRENDA references for 6.3.5.8 (Recommended.)
• PubMed references for 6.3.5.8
• PubMed Central references for 6.3.5.8
• Google Scholar references for 6.3.5.8
• Ye QZ, Liu J, Walsh CT (1990). "p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase". Proc. Natl. Acad. Sci. U. S. A. 87: 9391–5. doi:10.1073/pnas.87.23.9391. PMID 2251281. 
• Viswanathan VK, Green JM, Nichols BP (1995). "Kinetic characterization of 4-amino 4-deoxychorismate synthase from Escherichia coli". J. Bacteriol. 177: 5918–23. PMID 7592344. 

[edit] External links

The CAS registry number for this enzyme class is 132264-37-0.

• IUBMB entry for 6.3.5.8

• KEGG entry for 6.3.5.8

• BRENDA entry for 6.3.5.8

• NiceZyme view of 6.3.5.8

• EC2PDB: PDB structures for 6.3.5.8

• PRIAM entry for 6.3.5.8

• PUMA2 entry for 6.3.5.8

• IntEnz: Integrated Enzyme entry for 6.3.5.8

• MetaCyc entry for 6.3.5.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0046820: 4-amino-4-deoxychorismate synthase

• AMIGO entry for GO code 0046820: 4-amino-4-deoxychorismate synthase