Aminobutyraldehyde dehydrogenase

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In enzymology, an aminobutyraldehyde dehydrogenase (EC 1.2.1.19) is an enzyme that catalyzes the chemical reaction

4-aminobutanal + NAD⁺ + H₂O $\rightleftharpoons$ 4-aminobutanoate + NADH + 2 H⁺

The 3 substrates of this enzyme are 4-aminobutanal, NAD⁺, and H₂O, whereas its 3 products are 4-aminobutanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-aminobutanal:NAD+ 1-oxidoreductase. Other names in common use include gamma-guanidinobutyraldehyde dehydrogenase (ambiguous), ABAL dehydrogenase, 4-aminobutyraldehyde dehydrogenase, 4-aminobutanal dehydrogenase, gamma-aminobutyraldehyde dehydroganase, 1-pyrroline dehydrogenase, ABALDH, and YdcW. This enzyme participates in the urea cycle and the metabolism of amino groups and beta-alanine.

[edit] References

IUBMB entry for 1.2.1.19
BRENDA references for 1.2.1.19 (Recommended.)
PubMed references for 1.2.1.19
PubMed Central references for 1.2.1.19
Google Scholar references for 1.2.1.19
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