Amino esters

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Please improve this article if you can. (December 2007)

Structurally, local anesthetics consist of three molecular components:

The chemical linkage between the lipophilic part and the intermediate chain can be of the amide-type or the ester-type, and is the general basis for the current classification of local anesthetics.

Amino ester-type include:

Amino esters, in reference to anesthetic agents, are rapidly metabolized in the plasma by butyrlcholinesterase to para-aminobenzoic acid derivatives, then excreted in the urine. This suggests their very short ½ lives.

Allergy is more likely to occur with ester-type agents, as opposed to amide-type.

[edit] Reference

  • UT Med School, Pharmacology Syllabus.
  • Katsung. 10th edition. Chapter 26.
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