ALX4

From Wikipedia, the free encyclopedia

Aristaless-like homeobox 4

Identifiers

ALX4; FPP; PFM; PFM1; PFM2; KIAA1788

External IDs

OMIM: 605420 MGI: 108359 HomoloGene: 7229

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus • transcription factor complex
Biological Process:	• skeletal development • regulation of transcription from RNA polymerase II promoter • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021926 (mRNA)
NP_068745 (protein)

NM_007442 (mRNA)
NP_031468 (protein)

Location

Chr 11: 44.24 - 44.29 Mb

Chr 2: 93.44 - 93.48 Mb

Pubmed search

[1]

[2]

Aristaless-like homeobox 4, also known as ALX4, is a human gene.^[1]

[edit] References

^ Entrez Gene: ALX4 aristaless-like homeobox 4.

[edit] Further reading

Bartsch O, Wuyts W, Van Hul W, et al. (1996). "Delineation of a contiguous gene syndrome with multiple exostoses, enlarged parietal foramina, craniofacial dysostosis, and mental retardation, caused by deletions in the short arm of chromosome 11.". Am. J. Hum. Genet. 58 (4): 734–42. PMID 8644736.
Qu S, Tucker SC, Zhao Q, et al. (1999). "Physical and genetic interactions between Alx4 and Cart1.". Development 126 (2): 359–69. PMID 9847249.
Wu YQ, Badano JL, McCaskill C, et al. (2000). "Haploinsufficiency of ALX4 as a potential cause of parietal foramina in the 11p11.2 contiguous gene-deletion syndrome.". Am. J. Hum. Genet. 67 (5): 1327–32. PMID 11017806.
Wuyts W, Cleiren E, Homfray T, et al. (2001). "The ALX4 homeobox gene is mutated in patients with ossification defects of the skull (foramina parietalia permagna, OMIM 168500).". J. Med. Genet. 37 (12): 916–20. PMID 11106354.
Mavrogiannis LA, Antonopoulou I, Baxová A, et al. (2001). "Haploinsufficiency of the human homeobox gene ALX4 causes skull ossification defects.". Nat. Genet. 27 (1): 17–8. doi:10.1038/83703. PMID 11137991.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. PMID 11347906.
Boras K, Hamel PA (2002). "Alx4 binding to LEF-1 regulates N-CAM promoter activity.". J. Biol. Chem. 277 (2): 1120–7. doi:10.1074/jbc.M109912200. PMID 11696550.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wakui K, Gregato G, Ballif BC, et al. (2005). "Construction of a natural panel of 11p11.2 deletions and further delineation of the critical region involved in Potocki-Shaffer syndrome.". Eur. J. Hum. Genet. 13 (5): 528–40. doi:10.1038/sj.ejhg.5201366. PMID 15852040.
Mavrogiannis LA, Taylor IB, Davies SJ, et al. (2006). "Enlarged parietal foramina caused by mutations in the homeobox genes ALX4 and MSX2: from genotype to phenotype.". Eur. J. Hum. Genet. 14 (2): 151–8. doi:10.1038/sj.ejhg.5201526. PMID 16319823.