ALX1

From Wikipedia, the free encyclopedia

Cartilage paired-class homeoprotein 1

Identifiers

External IDs

OMIM: 601527 MGI: 104621 HomoloGene: 5075

Gene ontology
Molecular Function:	• transcription factor activity • transcription corepressor activity • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• cartilage condensation • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • multicellular organismal development • brain development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006982 (mRNA)
NP_008913 (protein)

NM_172553 (mRNA)
NP_766141 (protein)

Location

Chr 12: 84.2 - 84.22 Mb

Chr 10: 102.44 - 102.46 Mb

Pubmed search

[1]

[2]

Cartilage paired-class homeoprotein 1, also known as CART1, is a human gene.^[1]

The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly.^[1]

[edit] References

^ ^a ^b Entrez Gene: CART1 cartilage paired-class homeoprotein 1.

[edit] Further reading

Régnier CH, Tomasetto C, Moog-Lutz C, et al. (1995). "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma.". J. Biol. Chem. 270 (43): 25715-21. PMID 7592751.
Zhao GQ, Zhou X, Eberspaecher H, et al. (1993). "Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes.". Proc. Natl. Acad. Sci. U.S.A. 90 (18): 8633-7. PMID 7690966.
Zhao Q, Behringer RR, de Crombrugghe B (1996). "Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene.". Nat. Genet. 13 (3): 275-83. doi:10.1038/ng0796-275. PMID 8673125.
Gordon DF, Wagner J, Atkinson BL, et al. (1996). "Human Cart-1: structural organization, chromosomal localization, and functional analysis of a cartilage-specific homeodomain cDNA.". DNA Cell Biol. 15 (7): 531-41. PMID 8756334.
Cai RL (1998). "Human CART1, a paired-class homeodomain protein, activates transcription through palindromic binding sites.". Biochem. Biophys. Res. Commun. 250 (2): 305-11. doi:10.1006/bbrc.1998.9257. PMID 9753625.
Qu S, Tucker SC, Zhao Q, et al. (1999). "Physical and genetic interactions between Alx4 and Cart1.". Development 126 (2): 359-69. PMID 9847249.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Iioka T, Furukawa K, Yamaguchi A, et al. (2004). "P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain.". J. Bone Miner. Res. 18 (8): 1419-29. PMID 12929931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.