Alpha-santonin 1,2-reductase

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In enzymology, an alpha-santonin 1,2-reductase (EC 1.3.1.47) is an enzyme that catalyzes the chemical reaction

1,2-dihydrosantonin + NAD(P)+ alpha-santonin + NAD(P)H + H⁺

The 3 substrates of this enzyme are 1,2-dihydrosantonin, NAD⁺, and NADP⁺, whereas its 4 products are alpha-santonin, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase.

[edit] References

• IUBMB entry for 1.3.1.47
• BRENDA references for 1.3.1.47 (Recommended.)
• PubMed references for 1.3.1.47
• PubMed Central references for 1.3.1.47
• Google Scholar references for 1.3.1.47
• Naik U, Mavuinkurve S (1987). "alpha-Santonin 1,2-reductase and its role in the formation of dihydrosantonin and lumisantonin by Pseudomonas cichorii S". Can. J. Microbiol. 33: 658–62. PMID 3690421. 

[edit] External links

The CAS registry number for this enzyme class is 111070-23-6.

• IUBMB entry for 1.3.1.47

• KEGG entry for 1.3.1.47

• BRENDA entry for 1.3.1.47

• NiceZyme view of 1.3.1.47

• EC2PDB: PDB structures for 1.3.1.47

• PRIAM entry for 1.3.1.47

• PUMA2 entry for 1.3.1.47

• IntEnz: Integrated Enzyme entry for 1.3.1.47

• MetaCyc entry for 1.3.1.47

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047659: alpha-santonin 1,2-reductase

• AMIGO entry for GO code 0047659: alpha-santonin 1,2-reductase