Alpha-methylacyl-CoA racemase

From Wikipedia, the free encyclopedia

In enzymology, an alpha-methylacyl-CoA racemase (EC 5.1.99.4) is an enzyme that catalyzes the chemical reaction

(2S)-2-methylacyl-CoA (2R)-2-methylacyl-CoA

Hence, this enzyme has one substrate, (2S)-2-methylacyl-CoA, and one product, (2R)-2-methylacyl-CoA.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on other compounds. The systematic name of this enzyme class is 2-methylacyl-CoA 2-epimerase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1X74, 2G04, 2GCE, 2GCI, 2GD0, 2GD2, and 2GD6.

[edit] References

• IUBMB entry for 5.1.99.4
• BRENDA references for 5.1.99.4 (Recommended.)
• PubMed references for 5.1.99.4
• PubMed Central references for 5.1.99.4
• Google Scholar references for 5.1.99.4
• Schmitz W, Fingerhut R, Conzelmann E (1994). "Purification and properties of an alpha-methylacyl-CoA racemase from rat liver". Eur. J. Biochem. 222: 313–23. doi:10.1111/j.1432-1033.1994.tb18870.x. PMID 8020470. 

[edit] External links

The CAS registry number for this enzyme class is 156681-44-6.

• IUBMB entry for 5.1.99.4

• KEGG entry for 5.1.99.4

• BRENDA entry for 5.1.99.4

• NiceZyme view of 5.1.99.4

• EC2PDB: PDB structures for 5.1.99.4

• PRIAM entry for 5.1.99.4

• PUMA2 entry for 5.1.99.4

• IntEnz: Integrated Enzyme entry for 5.1.99.4

• MetaCyc entry for 5.1.99.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008111: alpha-methylacyl-CoA racemase

• AMIGO entry for GO code 0008111: alpha-methylacyl-CoA racemase