Alpha-enolase

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Enolase 1, (alpha)
Identifiers
Symbol(s) ENO1; ENO1L1; MBP-1; MPB1; NNE; PPH
External IDs OMIM: 172430 MGI: 95393 HomoloGene: 68183
EC number 4.2.1.11
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2023 13806
Ensembl ENSG00000074800 n/a
Uniprot P06733 n/a
Refseq NM_001428 (mRNA)
NP_001419 (protein)		 XM_001006583 (mRNA)
XP_001006583 (protein)
Location Chr 1: 8.84 - 8.98 Mb n/a
Pubmed search [1] [2]

Enolase 1, more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. It is a homodimer composed of 2 alpha subunits.

Contents

[edit] Relationship to Myc-binding protein-1

Its gene, the ENO1, also encodes the Myc-binding protein-1(MBP1), which downregulates the activity of c-myc protooncogene.[1] Alpha-enolase is the longer form (48 kDa) localized in both cytoplasm and nuclei, while MBP1 is shorter (37 kDa) and is found mostly in the nuclei.

[edit] Clinical significance

Alpha-enolase has been identified as an autoantigen in Hashimoto's encephalopathy.[2] Single studies have also identified it as an autoantigen associated with severe asthma[3] and a putative target antigen of anti-endothelial cell antibody in Behçet's disease.[4] Reduced expression of the enzyme has been found in the corneas of people suffering from keratoconus.[5][6]

[edit] See also

[edit] External links

[edit] References

  1. ^ Subramanian A, Miller DM. (2000) Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. J Biol Chem. 2000 Feb 25;275(8):5958-65. PMID 10681589 free full text
  2. ^ Yoneda M, Fujii A, Ito A, Yokoyama H, Nakagawa H, Kuriyama M. High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy. J Neuroimmunol. 2007 Apr;185(1-2):195-200. Epub 2007 Mar 1. PMID 17335908
  3. ^ Nahm DH, Lee KH, Shin JY, Ye YM, Kang Y, Park HS. (2006) Identification of alpha-enolase as an autoantigen associated with severe asthma. J Allergy Clin Immunol. 2006 Aug;118(2):376-81. Epub 2006 Jun 9. PMID 16890761 doi:10.1016/j.jaci.2006.04.002
  4. ^ Lee KH, Chung HS, Kim HS, Oh SH, Ha MK, Baik JH, Lee S, Bang D (2003) Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behcet's disease. Arthritis Rheum 2003, 48:2025-2035. PMID 12847697 free full text
  5. ^ Srivastava OP, Chandrasekaran D, Pfister RR. Molecular changes in selected epithelial proteins in human keratoconus corneas compared to normal corneas. Mol Vis. 2006 Dec 20;12:1615-25. PMID 17200661 free full text
  6. ^ Nielsen K, Vorum H, Fagerholm P, Birkenkamp-Demtroder K, Honore B, Ehlers N, Orntoft TF. Proteome profiling of corneal epithelium and identification of marker proteins for keratoconus, a pilot study. Exp Eye Res 2006; 82:201-9. PMID 16083875
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Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)
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