Alpha-amino-acid esterase

From Wikipedia, the free encyclopedia

In enzymology, an alpha-amino-acid esterase (EC 3.1.1.43) is an enzyme that catalyzes the chemical reaction

an alpha-amino acid ester + H₂O $\rightleftharpoons$ an alpha-amino acid + an alcohol

Thus, the two substrates of this enzyme are alpha-amino acid ester and H₂O, whereas its two products are alpha-amino acid and alcohol.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is alpha-amino-acid-ester aminoacylhydrolase. This enzyme is also called alpha-amino acid ester hydrolase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1MPX, 1NX9, 1RYY, 2B4K, and 2B9V.

[edit] References

IUBMB entry for 3.1.1.43
BRENDA references for 3.1.1.43 (Recommended.)
PubMed references for 3.1.1.43
PubMed Central references for 3.1.1.43
Google Scholar references for 3.1.1.43
Kato K, Kawahara K, Takahashi T and Kakinuma A (1980). "Purification of an alpha-amino acid ester hydrolase from Xanthomonas citri". Agric. Biol. Chem. 44: 1069–1074.
Kato K, Kawahara K, Takahashi T and Kakinuma A (1980). "Substrate specificity of an alpha-amino acid ester hydrolase from Xanthomonas citri". Agric. Biol. Chem. 44: 1075–1081.
Takahashi T, Yamazaki Y, Kato K (1974). "Substrate specificity of an alpha-amino acid ester hydrolase produced by Acetobacter turbidans A.T.C.C. 9325". Biochem. J. 137: 497–503. PMID 4424889.